Current Students—Matthew Gumbleton
PhD (3rd year)
Department: Microbiology & Immunology
Advisor: William Kerr, PhD
Natural killer (NK) cells express activating and inhibitory receptors,
termed the Natural Killer Receptor Repertoire (NKRR), that are
expressed in a variegated manner with individual receptor frequencies
and densities determined not only by promoter strength, but also by
the presence of MHC-I ligands. The signaling inputs from the
activating and inhibitory receptors expressed by an individual NK cell
determines it’s ability to respond to an infected or malignant cell.
Mice with germline deficiency in SHIP1 have severe NK cell
dysregulation, including increased NK cell numbers, deregulated NKRR
and inability to reject an MHC-mismatched bone marrow graft. It is
unknown if NK cell dysfunction is due to intrinsic effects of SHIP1 in
NK cells or due to the effect of SHIP1 deficiency in other immune cell
types that leads to an inflammatory milieu in SHIP1-/- mice. Using a
mouse model that enables NK selective ablation of SHIP1 expression,
NCR1iCreSHIP1flox/flox, we have begun to assess if the defects noted
previously are recapitulated in mice where only NK-lineage cells lack
Fuhler, G.M., Brooks, R., Toms, B., Iyer, S., Gengo,
E.A., Park, M.Y., Gumbleton, M., Viernes, D.R., Chisholm, J.D., and
Kerr, W.G. (2012). Therapeutic potential of SH2 domain-containing
inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer. Mol
Med 18, 65-75.
Puel A, Cypowyj S, Bustamante J, Wright JF, Liu L, Lim HK, Migaud M, Israel L, Chrabieh M, Audry M, Gumbleton M, Toulon A, Bodemer C, El-Baghdadi J, Whitters M, Paradis T, Brooks J, Collins M, Wolfman NM, Al-Muhsen S, Galicchio M, Abel L, Picard C, Casanova JL. (2011 0. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science. Apr 1;332(6025):65-8.
Dr. Arthur Kornberg (a Nobel prize winner in medicine in 1959) once said, "basic research is the lifeline of medicine." And if I could extend his comment, I would add, "and publication is the lifeline of medical research." I think publishing one's work serves two important roles. The first is to communicate your work to the larger scientific community, and the second is to serve as a landmark for the completion of one aspect of your work, thus providing direction for the future scientific work. As a future physician scientist here at Upstate, I have numerous opportunities to get involved in activities and trainings to improve our skills needed for publications.