Allen E Silverstone, PhD
Research Programs and Affiliations
- Biomedical Sciences Program
- Cancer Research Institute
- Microbiology and Immunology
- Research Pillars
Education & Fellowships
- Postdoctoral Fellow: MIT Cancer Center, 1978, Leukemia & Immunology
- PhD: Massachusetts Institute of Technology, 1970
- How dioxins and estrogens and estrogenic compounds affect the immune system.
Research AbstractMy program explores how dioxins, PCBs, and estrogenic compounds affect the immune system at the cellular and molecular level. We are using a combination of dioxin receptor (AhR) knock out and conditional knock out mice, Estrogen receptor knock-out mice (ER alpha and beta) and microarrays to identify the specific gene programs activated by these agents in the earliest developing T and B cells. Selected References
Laoisa, MD,A Wyman,FG Murante, NC Fiore, JE Staples, TA Gasiewicz, AE Silverstone (2003) Cell Proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor: J. Immunol. 171, 4582-4591.
Laiosa,MD, Z-W Lai, TS Thurmond, NC Fiore, C DeRossi, BC. Holdener, TA. Gasiewicz, and AE Silverstone. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Causes Alterations in Lymphocyte Development and Thymic Atrophy in Hemopoietic Chimeras Generated from Mice Deficient in ARNT2,Tox. Sci. 2002, 69,117-124
Eric Wohlford received a 2012 travel award from the American Society of Tropical Medicine and Hygiene and spent two months in Kenya working in the lab of Rosemary Rochford, PhD, professor and chair of Upstate’s Department of Microbiology & Immunology. Eric studied the effects of malaria on B cells (producers of antibodies that fight infection) and Epstein-Barr Virus infection in the region. “Tropical medicine is unique, in that small, focused improvements in patient care make dramatic improvements in the well-being of patients,” he said.