MD/PHD PROFILE
Eric Wolhford

Eric Wohlford

Eric studied the effects of malaria on B cells in Kenya. Read More...

Faculty

Golam Mohi, PhD

Golam Mohi, PhD
Appointed 09/05/06
6290 Weiskotten Hall
766 Irving Ave.
Syracuse, NY 13210

315 464-9861

Current Appointments

Hospital Campus

  • Downtown

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Pharmacology

Education & Fellowships

  • Postdoctoral Fellow: Harvard Medical School, 2005, Cancer Biology
  • PhD: University of Tokyo, 2001, Molecular and Cell Biology

Research Interests

  • Stem cell biology, cell signaling, hematopoiesis and blood cancer 

Clinical Trials

  • Identification of Potential New Therapies for Myeloproliferative Neoplasms
    Read more

Associations/Memberships

  • American Society of Hematology (ASH)
  • American Association for Cancer Research (AACR)

Publications

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Research

Research Abstract

My laboratory focuses on understanding the molecular and epigenetic mechanisms involved in the regulation of normal hematopoiesis and hematologic malignancies. The ultimate goal of our research is to identify new therapeutic targets and develop novel therapeutic strategies for treatment of leukemia. JAK2, a member of the Janus family of non-receptor protein tyrosine kinases (JAK), is activated in response to a variety of cytokines. A somatic point mutation (V617F) in the JAK2 tyrosine kinase has been found in a majority of patients with myeloproliferative neoplasms (MPN) including 95% cases of polycythemia vera (PV) and 50-60% cases of essential thrombocythemia (ET) and primary myelofibrosis (PMF). One of the major areas of our research is to define the role of JAK2 and JAK2V617F in hematopoiesis and in the pathogenesis of MPN. We are utilizing state-of-the-art techniques and genetically engineered mouse models to uncover the mechanisms involved in leukemogenesis.

Current research projects in my laboratory are focused in the following areas:

  • Elucidation of the role of JAK2 and JAK2V617F mutation in hematopoiesis and myeloproliferative neoplasms (MPN).
  • Investigation of the role of SHP2 in polycythemia vera (PV) and myelofibrosis (MF).
  • Investigation of the role of protein tyrosine phosphatase PTPN1 in myeloid neoplasms.
  • Investigation of the role of histone methyltransferase EZH2 in the pathogenesis of MF.
  • Testing the efficacy of potential new targeted therapies for MPN using novel animal models.

 

Selected Publications

Sattler M*, Mohi MG*, Pride YB, Quinnan LR, Malouf NA, Podar K, Gesbert F, Iwasaki H, Li S, Van Etten RA, Gu H, Griffin JD, Neel BG. Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell. 2002;1(5):479-92. PMID: 12124177 (*Co-first author).

Mohi MG, Boulton C, Gu TL, Sternberg DW, Neuberg D, Griffin JD, Gilliland DG, Neel BG. Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs. Proc Natl Acad Sci U S A. 2004;101(9):3130-5. PMID: 14976243

Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL, Yang W, Pao LI, Gilliland DG, Epstein JA, Neel BG. Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat Med. 2004;10(8):849-57. PMID: 15273746

Mohi MG, Williams IR, Dearolf CR, Chan G, Kutok JL, Cohen S, Morgan K, Boulton C, Shigematsu H, Keilhack H, Akashi K, Gilliland DG, Neel BG. Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Cancer Cell. 2005;7(2):179-91. PMID: 15710330

Chan G, Kalaitzidis D, Usenko T, Kutok JL, Yang W, Mohi MG, Neel BG. Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. Blood. 2009;113(18):4414-24. PMID: 19179468

Akada H, Yan D, Zou H, Fiering S, Hutchison RE, Mohi MG. Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood. 2010 Apr 29;115(17):3589-97. PMID: 20197548

Zou H, Yan D, Mohi G. Differential biological activity of disease-associated JAK2 mutants. FEBS Lett. 2011;585(7):1007-13. PMID: 21362419

Yan D, Hutchison RE, Mohi G. Critical requirement for Stat5 in a mouse model of polycythemia vera. Blood. 2012;119(15):3539-49. PMID: 22144185

Akada H, Akada S, Gajra A, Bair A, Graziano S, Hutchison RE, Mohi G. Efficacy of vorinostat in a murine model of polycythemia vera. Blood. 2012;119(16):3779-89. PMID: 22408262

Akada H, Akada S, Hutchison RE, Mohi G. Erythroid lineage-restricted expression of Jak2V617F is sufficient to induce a myeloproliferative disease in mice. Haematologica. 2012;97(9):1389-93. PMID: 22371173

Yan D, Hutchison RE, Mohi G. Tyrosine 201 is required for constitutive activation of JAK2V617F and efficient induction of myeloproliferative disease in mice. Blood. 2012;120(9):1888-98. PMID: 22837531

Akada H, Akada S, Hutchison RE, Sakamoto K, Wagner KU, Mohi G. Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells.  Stem Cells. 2014;32(7):1878-89. PMID: 24677703

Akada H, Akada S, Hutchison RE, Mohi G. Loss of wild-type Jak2 allele enhances myeloid cell expansion and accelerates myelofibrosis in Jak2V617F knock-in mice. Leukemia. 2014;28:1627-1635. PMID:24480985 

Yan D, Jobe F, Hutchison RE, Mohi G. Deletion of Stat3 enhances myeloid cell expansion and increases the severity of myeloproliferative neoplasms in Jak2V617F knock-in mice. Leukemia. 2015; 29(10):2050-61. PMID: 26044284

Gu S*, Chan WW*, Mohi G*, Rosenbaum J, Sayad A, Lu Z, Virtanen C, Li S, Neel BG, Van Etten RA. Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1. Blood. 2016; 127(14):1803-13. PMID: 26773044 (*Co-first author).

Yang Y, Akada H, Nath D, Hutchison RE, Mohi G.Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm.  Blood. 2016; 127(26):3410-23. PMID: 27081096

Complete list of my published work in MyBibliography:

http://www.ncbi.nlm.nih.gov/sites/myncbi/1tyYtiGcvB15n/bibliograpahy/43449926/public/?sort=date&direction=descending

Faculty Profile Shortcut: http://www.upstate.edu/faculty/mohim