George Holz profile picture
315 464-9841

George Holz, PhD

4310 Institute For Human Performance (IHP)
505 Irving Avenue
Syracuse, NY 13210
George Holz's email address generated as an image

CURRENT APPOINTMENTS

Professor of Medicine
Professor of Pharmacology

LANGUAGES

English

WEB RESOURCES

RESEARCH PROGRAMS AND AFFILIATIONS

Medicine

RESEARCH INTERESTS

Drug development for the treatment of type 2 diabetes mellitus.

EDUCATION

PhD: University of Illinois College of Medicine at Chicago, 1984, Pharmacology
BS: Cornell University, 1975, Physiology

RESEARCH ABSTRACT

Drug discovery research in the Holz laboratory at SUNY Upstate seeks to establish new pharmacological approaches to the treatment of type 2 diabetes and obesity. In this regard, our prior findings helped lead to FDA approval of the GLP-1 receptor agonists Byetta, Victoza, Ozempic and Wegovy as new blood glucose-lowering agents with appetite-suppressing properties. One focus of the laboratory now concerns synthetic hyprid peptides with GPCR activating properties, as validated in high-throughput FRET assays using cAMP and Ca2+ biosensors. Such hybrid peptides incorporating amino acid motifs within GLP-1, Glucagon, GIP and Peptide YY are likely to be of a unique medical importance in that they have the potential to exhibit novel dual or tri agonist properties with subcutaneous administration.

 

PUBLICATIONS

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