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315-464-5294

Melanie Comito, MD

CURRENT APPOINTMENTS

Professor of Pediatrics
Division Chief of Hematology and Oncology
Division Chief of Pediatrics

SPECIALTIES

Pediatrics
Pediatric Hematology/Oncology

LANGUAGES

English

PATIENT TYPE

Children

CLINICAL INTERESTS AND APPROACH TO CARE

Brain and Spinal Cord tumors in Children/Adolescents

CLINICAL TRIALS

INCB 18424-269 (COG AALL1521), A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2 Rearranged and/or JAK Pathway–Mutant Acute Lymphoblastic Leukemia
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International Registry for Severe Chronic Neutropenia
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Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research Network (CCRN)
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Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer
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Umbrella Long-Term Follow-Up Protocol
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Key Adverse Events Following Childhood Cancer
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4941L: National Wilms Tumor Late Effects Study
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Treatment for Patients with Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor: A Groupwide Phase III Study
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Renal Tumors Classification, Biology and Banking Study
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A Randomized Phase II study of Brentuximab Vedotin (NSC# 749710) and Crizotinib (NSC# 749005) in Patients with Newly Diagnosed Anaplastic Large Cell Lymphoma
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Intergroup Trial for Children or Adolescents with B-cell Non-Hodgkin Lymphoma NHL or Mature B-cell Leukemia B- AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients.
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Rare and Cutaneous Non-Hodgkin Lymphoma Registry
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Pilot Study Using Myeloablative Busulfan/Melphalan (BuMel) Consolidation Following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma
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Neuroblastoma Biology Studies
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Phase III Randomized Study of Chimeric Antibody 14.18 (Ch14.18) in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue
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Treatment of Children with All Stages of Hepatoblastoma
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A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens
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A COG Soft Tissue Sarcoma Diagnosis, Biology and Banking Protocol
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A Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chermotherapy in Initial Treatment of non-metastatic Ewing Sarcoma
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A Children's Oncology Group Protocol for Collecting and Banking Ewing Sarcoma Specimens
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Phase II Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT): A Groupwide Phase II Study
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A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytoma and Optic Pathway Gliomas
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Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years
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Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus Bevacizumab for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial
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A Phase III Randomized Trial for Patients with de novo AML using Bortezomib and Sorafenib (IND#114480; NSC# 681239, NSC# 724772) for Patients with High Allelic Ratio FLT3/ITD
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Biology Study of Transient Myeloproliferative Disorder (TMD) in Children with Down Syndrome (DS)
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A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum
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(CA180372) A Phase II Multi-Center, Historically-Controlled Study of Dasatinib Added to Standard Chemotherapy in Pediatric Patients with Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
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Treatment of Patients with Newly Diagnosed Standard Risk B-Precursor Acute Lymphoblastic Leukemia (ALL): A Groupwide Phase III Study
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Classification of Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)
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A study of neurocognitive function in children treated for ALL
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A Phase III Study of Risk Directed Therapy for Infants with Acute Lymphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +/- FLT3 Inhibition
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A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens
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Intensified Methotrexate, Nelarabine (Compound 506U78; IND# 52611) and Augmented BFM Therapy for Children and Young Adults with Newly Diagnosed T-cell Acute Lymphoblastic Leukemia
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DISEASES & CONDITIONS TREATED

Bleeding Disorders
Childhood Cancers

TREATMENTS / SERVICES

Blood Transfusion
Bone Marrow Aspiration
Bone Marrow Biopsy
Chemotherapy
Clinical Trials
Genetic Testing
Infusional Therapies
Lumbar Puncture
Radiation Therapy
Stem Cell Transplantation

CLINICAL LOCATIONS

Upstate Cancer Center
750 East Adams Street
Syracuse, NY 13210
315-464-5294

CLINICAL SECTION AFFILIATIONS

Pediatrics
Hematology and Oncology

CURRENT HOSPITAL PRIVILEGES

Upstate University Hospital
Crouse Hospital

PREVIOUS APPOINTMENTS

Penn State University College of Medicine, 1999-2016