Major Research Areas
Genomics, Proteomics and Bioinformatics
With the genomes of many model organisms as well as humans completely sequenced, the challenge of the future is to relate sequence information to biological function and develop new ways to manipulate genomes for both investigative and therapeutic purposes. To stay at the forefront of this second renaissance in genetics, SUNY Upstate has collected necessary expertise and equipment, including: state-of-the-art facilities for whole genome genetic interaction analysis, protein microarrays and sensitive mass-spectrometry for protein complex analysis, DNA microarrays for gene expression and human linkage analysis, and the computer core facilities and bioinformatics expertise to analyze the resulting large datasets. As a result, our investigators are internationally recognized for contributions in the areas of transgenic animals, gene expression systems and gene replacement strategies, gene function discovery, human gene disease mapping and discovery, and genetic network discovery. Approaches include site-specific recombinases, viral gene delivery vectors, microarray analysis, proteomics, whole genome protein interaction analysis, and mass spectrometry.
David Amberg, Ph.D.
Professor
Regulation of actin dynamics and analysis of genomic influences on actin function. |
Arkadii Perzov, Ph.D.
Professor
Biophysical mechanisms of cardiac arrhythmias; fluorescence imaging. |
Edward Berry, Ph.D.
Assistant Professor
Biological energy transduction by membrane protein complexes, with emphasis on oxidative phosphorylation and photosynthesis. |
Francesca Pignoni, Ph.D.
Associate Professor
Neurogenesis; Retinal Progenitor Cells Specification and Proliferation; Genetic Control of Stem Cell Identity and Maintenance; Genetic Pathways in RPE Formation; Disease Genes Analysis in Drosophila
|
Stephen Glatt, Ph.D.
Assistant Professor
Psychiatric Epidemiology and Genetics |
Mark Schmitt, Ph.D.
Associate Professor
Ribonucleoprotein assembly and biogenesis; mitochondrial RNA import, mRNA degradation, cell cycle control |
Steven Goodman, Ph.D.
Professor
Proteomic assessment of sickle cell severity. |
Allen Silverstone, Ph.D.
Professor
How dioxins and estrogens and estrogenic compounds affect the immune system. |
Ying Huang, M.D., Ph.D.
Associate Professor
Oncogenic signaling in cellular transformation and apoptosis; tumor suppressor genes. |
Andrea Viczian, Ph.D.
Assistant Professor
Mammalian retinal stem cells formation; molecular mechanism of retinal cell fate decisions; using cell replacement therapy to heal the blinded eye. |
Patricia Kane, Ph.D.
Professor and Chair
Vacuolar H+ATPases (structure, function, assembly and regulation), cellular pH homeostasis, cellular stress responses, protein sorting, genomics, yeast as a model system |
Richard JH Wojcikiewicz, Ph.D.
Professor
Intracellular signaling via InsP3 receptors and the ubiquitin/proteasome pathway. |
Stewart Loh, Ph.D.
Professor
Mechanism and kinetics of protein folding; protein-based molecular switches; protein engineering and design; structure and function of the p53 tumor suppressor. |
Michael Zuber, Ph.D.
Assistant Professor
The molecular basis of retinal stem cell formation; regulating retinal stem/progenitor cell proliferation; using retinal stem/progenitor cells to heal the injured or degenerating retina. |
Andras Perl, M.D., Ph.D.
Professor
Genes and Viruses Predisposing to Autoimmunity, Genetics, Apoptosis, Endogenous Retroviruses, Transaldolase |
Back to Research Areas List
Complete Faculty List
|
|
What's the
SUNY Upstate Difference?
Researcher Improves Bone Marrow Transplant Success Rate in MiceAt SUNY Upstate Medical University, researchers are dedicated to unlocking the mysteries of human health and illness.
William Kerr, a former Newman Scholar of the Leukemia & Lymphoma Society, brought more than $3.8 million in NIH funding this year to SUNY Upstate. Kerr investigates the role a novel gene (LRBA) plays in cancer cells, and studies a particular enzyme (SHIP) involved in the rejection of bone marrow and organ transplants. More >
|
