Major Research Areas
Cytoskeleton
In addition to providing the structural support for cells, dynamic remodeling of the cytoskeleton is required for numerous cellular events including migration, mitosis, exocytosis and endocytosis, adhesion, growth control, and others. Researchers at Upstate are working to understand the regulation and function of the three primary cytoskeletal networks: intermediate filaments, microtubules, and actin as well as the molecular motors, adaptor proteins, activation pathways, and inherent biochemical properties involved in cytoskeletal regulation and function. Scientific approaches to cytoskeletal study vary greatly and include molecular cloning and mutagenesis, model organisms, light, video, electron, and fluorescent microscopy, protein biochemistry and numerous in vitro assays of cellular behavior.
David Amberg, Ph.D.
Professor
Regulation of actin dynamics and analysis of genomic influences on actin function. |
Eric Olson, Ph.D.
Assistant Professor
Cellular and molecular mechanisms of cerebral cortex development. |
Scott Blystone, Ph.D.
Associate Professor
Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype. |
Thomas Poole, Ph.D.
Associate Professor
Vascular development and the alignment of growing nerves and blood vessels in quail and zebrafish embryos. |
Dipak Dube, Ph.D.
Professor
Molecular mechanism of cardiac myofibrillogenesis in vertebrates. |
David Pruyne, Ph.D.
Assistant Professor
Biochemistry and cell biology of formins as actin cytoskeleton organizers, using Caenorhabditis elegans as a model system.
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Steven Goodman, Ph.D.
Professor
Proteomic assessment of sickle cell severity. |
Jean Sanger, Ph.D.
Professor
Analysis of the assembly of the actin/myosin cytoskeleton in muscle and non-muscle cells. |
Ying Huang, M.D., Ph.D.
Associate Professor
Oncogenic signaling in cellular transformation and apoptosis; tumor suppressor genes. |
Joseph Sanger, Ph.D.
Professor and Chair
Cellular analysis of the formation of myofibrils, stress fibers, and cleavage furrows in living cells. |
Mira Krendel, Ph.D.
Assistant Professor
Physiological functions of myosin motors and their roles in diabetic kidney disease and cancer
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Vladimir Sirotkin, Ph.D.
Assistant Professor
Mechanisms of the actin cytoskeleton assembly and role of myosin-1 during endocytosis in fission yeast. |
David Mitchell, Ph.D.
Professor
Regulation of ciliary dynein activity and assembly, and the role of the central pair complex in ciliary motility regulation. |
Christopher Turner, Ph.D.
Professor
Regulation of cell migration by focal adhesion adapter proteins and their role in cancer cell metastasis.
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Complete Faculty List
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What's the
SUNY Upstate Difference?
Researcher Improves Bone Marrow Transplant Success Rate in MiceAt SUNY Upstate Medical University, researchers are dedicated to unlocking the mysteries of human health and illness.
William Kerr, a former Newman Scholar of the Leukemia & Lymphoma Society, brought more than $3.8 million in NIH funding this year to SUNY Upstate. Kerr investigates the role a novel gene (LRBA) plays in cancer cells, and studies a particular enzyme (SHIP) involved in the rejection of bone marrow and organ transplants. More >
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