Major Research Areas

Upstate boasts basic and clinical researchers with diverse expertise in neuroscience, molecular genetics, genomics, epigenetics, structural biology, infectious disease, and behavior disorders. This allows students the opportunity to perform research in a wide range of research areas and easily collaborate when new expertise is needed.

Debashis Ghosh, MSc, PhD

Debashis Ghosh, MSc, PhD
Appointed 08/02/10
6310 Weiskotten Hall
766 Irving Ave.
Syracuse, NY 13210

315 464-9677

Current Appointments

Hospital Campus

  • Downtown

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Cancer Research Institute
  • Pharmacology
  • Research Pillars

Research Interests

  • Structure and function of enzymes in estrogen and androgen biosynthesis; rational design of enzyme modulators in hormonal breast and prostate cancers; characterization of interphotoreceptor retinol binding proteins.

HealthLinkOnAir Radio Interview

9/12/14 The promise of aromatase inhibitors in treatment of breast cancer

5/15/13 How will the NIH grant funding sequester affect local research?

1/9/11 Breast cancer research

Research Abstract

Selected Publications

  • Lo, J., Di Nardo. G., Griswold, J., Egbuta, C., Jiang, W., Gilardi, G., Ghosh, D. Structural Basis For Functional Roles Of Critical Residues In Human Cytochrome P450 Aromatase. Biochemistry DOI: 10.1021/Bi400669h (2013) (In Press)
  • Ghosh, D., Lo, J., Morton, D., Valette, D., Xi, J., Griswold, J., Hubbell, S., Egbuta. C., Jiang, W., An, J., Davies, H. M. Novel Aromatase Inhibitors By Structure-Guided Design. J. Med. Chem. 55, 8464-8476 (2012)
  • Jiang, W., Ghosh D. Ligand-Binding Interaction, Motion And Flexibility In Human Aromatase. Plos One 7, E32565 (2012)
  • Ghosh, D., Jiang, W., Lo, J., Egbuta, C. Higher Order Organization Of Human Placental Aromatase. Steroids 76, 753-758 (2011)
  • Ghosh, D., Griswold, J., Erman, M., Pangborn, W. X-Ray Structure Of Human Aromatase Reveals An Androgen-Specific Active Site. J. Steroid Biochem. Mol. Biol. 118, 197-202 (2010)
  • Ghosh, D., Griswold, J., Erman, M., Pangborn, W. Structural Basis For Androgen Specificity And Oestrogen Synthesis In Human Aromatase. Nature 457, 219-223 (2009)
    • [News & Views: Anticancer Drug Target Pictured. Nature 457, 159-169 (2009)]
  • Ghosh, D. Human Sulfatases: A Structural Perspective To Catalysis. Cellular And Molecular Life Sciences 64, 2013-2022 (2007) (Cover)
  • Chang, C-C, Hernandez-Guzman, F G, Luo, W, Wang, X, Ferrone, S, Ghosh, D. Structural Basis Of Antigen Mimicry In A Clinically Relevant Human Melanoma Antigen System. J. Biol. Chem. 280, 546-552 (2005)
  • Ghosh, D. Three-Dimensional Structures Of Sulfatases. Methods In Enzymology 400, 273-293 (2005)
  • Ghosh, D. Mutations In X-Linked Ichthyosis Disrupt The Active Site Structure Of Estrone/DHEA Sulfatase. Biochim. Biophys. Acta, Molecular Basis Of Disease. 1739, 1-4 (2004)
  • Hernandez-Guzman, F.G., Higahasiyama, T., Pangborn, W., Osawa, Y., Ghosh, D. Structure Of Human Estrone Sulfatase Suggests Functional Roles Of Membrane Association. J. Biol. Chem. 278, 22989-22997 (2003)
  • Ghosh, D., Sawicki, M., Pletnev, V., Erman, M., Ohno, S., Nakajin, S., Duax, W.L., Porcine Carbonyl Reductase: Structural Basis For A Functional Monomer In Short-Chain Dehydrogenases/Reductases. J. Biol. Chem. 276, 18457-18463 (2001)
  • Ghosh, D., Sawicki, M., Lala, P., Erman, M., Pangborn, W., Eyzaguirre, J., Gutierrez, R., Jornvall, H., Thiel, D. Multiple Conformations Of Catalytic Serine And Histidine In Acetylxylan Esterase At 0.90 Å. J. Biol. Chem. 276, 11159-11166 (2001)
  • Sawicki, M., Erman, M., Puranen, T., Vihko, P., Ghosh, D. Structure Of The Ternary Complex Of Human 17b-Hydroxysteroid Dehydrogenase Type 1 With Equilin And NADP+. Proc. Natl. Acad. Sci. USA 96, 840-845 (1999)
  • Ghosh, D., Erman, M., Sawicki, M., Lala, P., Weeks, D.R., Li, N., Pangborn, W., Thiel, D.J., Jörnvall, H., Eyzaguirre, J., Determination Of A Protein Structure By Iodination: The Structure Of Iodinated Acetylxylan Esterase. Acta Crystallograhica D, Biological Crystallography D55, 779-784 (1999)
  • Duax, W.L., Ghosh, D., Structure And Function Of Steroid Dehydrogenases Involved In Hypertension, Fertility And Cancer. Steroids 62, 95-100 (1997)
  • Ghosh, D., Wawrzak, Z., Pletnev, V., Li, N., Kaiser, R., Pangborn, W., Jörnvall,H., Erman,M., Duax, W.L., Structure Of Uncomplexed And Linoleate-Bound Candida Cylindracea Cholesterol Esterase. Structure 3, 279-288 (1995)
  • Ghosh, D., Pletnev, V.Z., Zhu, D.-W., Wawrzak, Z., Duax, W.L., Pangborn, W., Labrie, F., Lin, S.-X., Structure Of Human Estrogenic 17b-Hydroxysteroid Dehydrogenase At 2.20Å Resolution. Structure 3, 503-513 (1995)
  • Jörnvall, H., Persson, B., Krook, M., Atrian, S. Gonzalez-Duarte, R., Jeffery, J., Ghosh, D. Short-Chain Dehydrogenases/Reductases (SDR). Biochemistry 34, 6003-6013 (1995)
  • Ghosh, D., Wawrzak, Z., Weeks, C.M., Duax, W.L., Erman, M. The Refined Three-Dimensional Structure Of 3a,20b-Hydroxysteroid Dehydrogenase And Possible Roles Of The Residues Conserved In Short-Chain Dehydrogenases. Structure 2, 629-640 (1994)
  • Ghosh, D., Erman, M., Wawrzak, Z., Duax, W.L., Pangborn, W. Mechanism Of Inhibition Of 3a,20b-Hydroxysteroid Dehydrogenase By A Licorice-Derived Steroidal Inhibitor. Structure 2, 973-980 (1994)
  • Ghosh, D., Weeks, C.M., Grochulski, P., Duax, W.L., Erman, M., Rimsay, R.L., Orr, J.C. Three-Dimensional Structure Of Holo 3a,20b-Hydroxysteroid Dehydrogenase: A Member Of The Short Chain Dehydrogenase Family. Proc. Natl. Acad. Sci. USA 88, 10064-10068 (1991)

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