My lab studies brain development and brain function in individuals with genetic disorders. The main focus of our work is on a genetic disorder called 22q11.2 Deletion Syndrome (22q11DS). Individuals with 22q11DS are at a 25-fold greater risk for developing schizophrenia than individuals in the general population. We examine the effects of genetic mutation, brain development, and neuropsychological function in youth with this disorder, in order to identify the factors that place youth at highest risk for developing schizophrenia. Eventually, our research may allow us to identify and provide early interventions to youth at high risk for schizophrenia, potentially easing the huge toll that schizophrenia takes on families. Another focus of our work is to determine the effectiveness of computer-based, on-line, cognitive interventions in youth with genetically based intellectual disorders. Our hope is that by demonstrating the effectiveness of on-line, cognitive interventions, we can reach and benefit many youth who may not have access to centers that are providing such interventions in person.