Joseph B Domachowske, MD

Joseph B Domachowske, MD
Appointed 06/26/89
5400 Upstate University Hospital - Downtown Campus
750 East Adams Street
Syracuse, NY 13210

315 464-6331

Current Appointments

Hospital Campus

  • Downtown

Clinical Section Affiliations

  • Pediatrics: Infectious Disease

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Pediatrics
  • Research Pillars


Education & Fellowships

  • Fellowship: National Intsitutes of Health, Laboratory of Host Defenses, 1997
  • Residency: SUNY Health Science Center at Syracuse, 1992
  • MD: SUNY Health Science Center at Syracuse, 1989

Clinical Interests

  • Pediatric infectious diseases

Research Interests

  • Pneumovirus pathogenesis.

Clinical Trials

  • A phase 1b/2a randomized, double-blind, placebo-controlled, dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of MEDI8897, a monoclonal antibody with an extended half-life against respiratory syncytial virus, in healthy preterm infants
    Read more
  • A prospective, epidemiological study to assess the disease burden of respiratory syncytial virus (RSV) associated, suspected lower respiratory tract infections (LRTIs) in newborns, from birth up to 2 years of age.
    Read more
  • A single-center in vitro study to evaluate GSK 1325756 inhibition of CD11b cell surface expression in healthy adults and respiratory syncytial virus-infected children <2 years
    Read more
  • An observer-blind study to assess the safety, reactogenicity and immunogenicity of different formulations of GSK Biologicals’ investigational RSV vaccine (GSK3003891A), in healthy women
    Read more
  • Immunogenicity and safety study of GSK Biologicals’ quadrivalent influenza vaccine (GSK2282512A) compared to Fluzone® Quadrivalent in children 6 to 35 months of age. 201234 (FLU-Q-QIV-022)
    Read more
  • The SENTINEL 1 Study: An Observational, Non-Interventional Study in the United States to Characterize Respiratory Syncytial Virus Hospitalizations among Infants Born at 29 to 35 Weeks Gestational Age Not Receiving Immunoprophylaxis
    Read more

Specialties & Certification

  • Pediatrics
  • Pediatric Infectious Diseases

Diseases & Conditions Treated

  • Antibiotic-Associated Diarrhea
  • Antibiotic-Resistant Infections
  • Bacterial Meningitis in Children
  • Fever
  • Giardiasis
  • HIV Infection and AIDS
  • Herpes Encephalitis
  • Immune Abnormalities
  • Infections of Bones and Joints
  • Infectious Mononucleosis
  • Infective Endocarditis
  • Pneumonia
  • Shingles
  • Tuberculosis (TB)
  • Viral Infections in Children
  • Viral Meningitis in Children
  • Yeast Infection or Candidiasis


  • Children


  • Infectious Diseases Society of America (IDSA)
  • American Academy of Pediatrics

Current Hospital Privileges

  • Upstate University Hospital

HealthLinkOnAir Radio Interview

10/6/13 Improving immunization rates in low-income populations

7/25/13 The growing incidence of HPV and its connection to oral sex

8/19/12 Whooping cough cases are on the rise

5/6/12 Antibiotic resistance


Link to PubMed External Icon (Opens new window. Close the PubMed window to return to this page.)

Research Abstract

My laboratory program focuses on the molecular interactions between pneumoviruses and pulmonary epithelium. Short term goals include understanding the mechanisms of virus-induced alterations in epithelial cell gene expression. Longer term goals include developing and characterizing specific anti-viral and anti-inflammatory interventions for the treatment of viral bronchiolitis. We study these interactions in vitro, using tissue culture models, and in vivo using our rodent model of pneumovirus infection. Recently, we have also been successful in demonstrating the physiologic significance of results from our model systems in samples obtained from human infants with severe respiratory syncytial virus bronchiolitis.
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Practice/Contact Information

Immunology and Infectious Disease Program

Upstate University Hospital - Downtown Campus Maps and Directions
Address: 4W, 750 East Adams St., Syracuse, NY 13210
Phone: 315 464-1996
Fax: 315 464-7564
New Patient Phone: 866 543-KIDS (5437)
Insurance Info: Pediatric Service Group, LLP

Pediatric Designated AIDS Center

Upstate University Hospital - Downtown Campus Maps and Directions
Address: 4W, 750 East Adams St., Syracuse, NY 13210
Phone: 315 464-6331
New Patient Phone: 866 543-KIDS (5437)
Website: Pediatric Designated AIDS Center
Insurance Info: Pediatric Service Group, LLP

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