Genomic Psychiatry Cohort

STUDY SPONSOR: National Institute of Mental Health
Approved by the SUNY Upstate Medical University Institutional Review Board

Background/ Purpose:

The purpose of this multi-site study is to collect clinical data and DNA from 10,000 patients with schizophrenia, as well as from 10,000 normal controls. This very large sample will help us to investigate genetic differences that may exist between subjects with schizophrenia and healthy control subjects. Our site at Upstate Medical University in Syracuse is expected to recruit 1,000 subjects with schizophrenia and 1,000 normal controls over the course of five years. 

If this study leads to the successful finding of genes that influence the development, treatment, or course of schizophrenia, then it may be possible in the future to develop better diagnostic tests and improved treatments, as well as measures to prevent this serious disorder.

WE ARE PRESENTLY RECRUITING PEOPLE:

  • WITH SCHIZOPHRENIA or BIPOLAR DISORDER, AS WELL AS
  • HEALTHY 'CONTROL' SUBJECTS WITH NO PERSONAL OR FAMILY HISTORY OF SCHIZOPHRENIA OR PSYCHOSIS

TO PARTICIPATE IN THIS STUDY.

Study Procedure:

The entire procedure should take 1 ½ - 2 hours for subjects with schizophrenia, and about a half-hour for healthy control sujects. It consists of the following:

  • Participants will complete a brief screening questionnaire to determine eligibility into either the diagnostic group (schizophrenia) or the healthy control group.
  • Participants who agree to become study subjects will be guided through the informed consent process.
  • Participants exhibiting symptoms of schizophrenia will be administered a structured and private diagnostic interview, during which core clinical data related to their mental health will be collected, a medical history will be gathered, and demographic data such as race and ethnicity will be collected.
  • Participants in both groups will donate a small sample of blood, about 2-3 tablespoons.
  • In appreciation of their time spent in this study, participants in the diagnostic group will be given $50 and those in the healthy control group will be given $25.

Inclusion Criteria- Clinical Sample:

  • All participants must be 18 years of age or older.  There is no upper age exclusion as long as the participant can give informed consent and we can obtain reliable information.
  • A primary diagnosis of schizophrenia is essential (any subtype), and it must be confirmed by medical records, psychiatric personnel, or our diagnostic screening tool. 
  • It should also be noted that it’s acceptable for subjects to have other co-morbid diagnoses.

Inclusion Criteria- Control Sample:

  • All participants must be 18 years of age or older.  Again, there is no upper age exclusion.
  • Participants must have no history of, or exhibit any signs of, schizophrenia or psychosis, nor have a family history of schizophrenia in first-degree relatives.

Exclusion Criteria- Both Samples:

  • Psychiatrically unstable individuals (threat of violence, etc) will be excluded from the study in order to protect the rights and welfare of both the research team and vulnerable subjects.
  • Subjects will not be entered in to the study if they either appear to have reservations about participation or appear not to have understood the consent process.
  • Cases that are diagnostically unclear will be excluded from the study.
  • Only one person per family can participate.

Co-Principal Investigators for SUNY Upstate Medical University site:
Mantosh Dewan MD and Christopher Morley PhD

For more information, please contact Evelyn Fredericks, R.N. at: (315) 464 - 6943 or gpc@upstate.edu

YOUR HELP IS GREATLY APPRECIATED!!!

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