Research Faculty & Scientific Programs
Education and Clinical TrainingPh.D.: 1998, University of California at Los Angeles, NeurosciencePostdoctoral Fellow: 1999, Marshall-Sherfield Fellow, University of Cambridge, Developmental Biology Postdoctoral Fellow: 2002, University of Cambridge, Cambridge, England, Developmental Biology Research Program and Department AffiliationsBiochemistry and Molecular BiologyBiomedical Sciences Program Ophthalmology Research InterestsMammalian retinal stem cells formation; molecular mechanism of retinal cell fate decisions; using cell replacement therapy to heal the blinded eye.Research AbstractMy lab is interested in understanding the normal developmental pathway of retina cell genesis. We are using the mouse embryo as our guide. Our goal is to repeat the early developmental stages of embryonic eye formation starting with isolated mouse embryonic stem cells. Extrinsic and intrinsic factors in the mouse embryo play critical roles in transforming the pluripotent embryonic stem cell into the differentiated retinal cell. My lab is interested in the molecular pathways necessary for their formation, testing the necessity of these pathways using cultured mouse embryonic stem cells. Selected Publications: Viczian, A.S., Solessio, E.C., Lyou, Y. and Zuber, M.E. (2009) Generation of functional eyes from pluripotent cells. PLoS Biol. 7(8):e1000174. Verardo, M., Viczian, A.S., Piri, N., Akhmedov, N., Knox, B. and D.B. Farber. (2009) Regulatory sequences in the 3' untranslated region of the human cGMP-Phosphodiesterase β-Subunit gene. Invest Ophthalmol Vis Sci. 50(6):2591-8. Viczian, A.S., Bang, A., Harris, W.A. and Zuber, M.E. (2006) Expression of Xenopus laevis Lhx2 during eye development and evidence for divergent expression among vertebrates. Dev Dyn 235(4):1133-41. Viczian, A.S., Verardo, M., Zuber, M.E., Knox, B.E. and D.B. Farber. (2004) Conserved transcriptional regulation of a cone phototransduction gene in vertebrates. FEBS Letters 577: 259-264. Viczian, A.S., Vignali, R., Zuber, M.E., Barsacchi, G. and W.A. Harris. (2003) XOtx5b and XOtx2 regulate photoreceptor and bipolar fates in the Xenopus retina. Development 130: 1281-1294. Zuber, M.E., Gestri, G.*, Viczian, A.S.*, Barsacchi, G. and W.A. Harris. (2003) Specification of the vertebrate eye by a network of eye field transcription factors. Development, 130(21):5155-67. (*these authors contributed equally to this work). Perron, M., Boy, S., Amato, M.A., Viczian, A., Koebernick, K., Pieler, T. and W.A. Harris. (2003) A novel function for Hedgehog signaling in retinal pigment epithelium differentiation. Development 130: 1565-1577.
Publications - link to PubMedNote: The above PubMed link opens a new window. Close the PubMed window to return to this page.This profile was last updated on 09/04/2009 A short link is available for this profile: |
