Immune Response to CNS virus infections; Growth Factors for Post-Polio Syndrome; Immune-mediated diseases; Treatment of Multiple Sclerosis
How to take an accurate Neurological History; How to do an accurate Neurological Exam; MRI scans
CNS acute and chronic polio- and entero-virus infections; Growth factors for Post-Polio Syndrome; Treatment of Multiple Sclerosis; Amyotrophic Lateral Sclerosis (ALS) Motor Neuron Gene Expression
Post-Polio Syndrome(PPS) in the Mouse. We have developed a model of PPS in the mouse in order to analyze pathogenesis and try different modalities of treatment. The growth factors GDNF and IGF1 have resulted in improved strength of the Post-Polio mouse.
Amyotrophic Lateral Sclerosis (ALS) Motor Neuron Gene Expression. Motor neurons have been isolated from autopsy spinal cords of ALS patients and controls. RNA has been isolated from these motor neurons and cDNA libraries have been constructed. Subtraction of these libraries has begun in an attempt to identify motor neuron specific genes and gene products.
Multiple Sclerosis Treatment. Mechanisms of action of present MS disease modifying agents. Development of new disease modifying agents.
1. Christophi GP, Christophi JA, Gruber RC, Mihai C, Mejico LJ, Jubeltb. Quantitative differences in the immunomodulatory effects of Rebif and Avonex in IFN-B 1a treated multiple sclerosis patients. J Nourol Sci 2011; 307: 41-45.
2. Jubelt B, Mihai C, Li TM, Veerapaneni P. Rhombencephalitis / Brainstem Encephalitia. Curr Neurol Neurosci Rep 2011; 11:
3. Kister I et al. Rapid disaese course in African Americans with multiple sclerosis. Neurology 2010; 75: 217-223.
4. Jubelt B et al. Retrograde viral delivery of GDNF and IGF1 prevents the development of late weakness (Post-Polio Syndrome) in a mouse model. Neurology 2009 (suppl 3):A362.