Unit 1

Goals of this segment:

Segment A is an up-to-date overview of topics in cellular and molecular biology. The lectures will provide a foundation on which many other subjects in medical school will be based.

The key element in this segment is DNA (deoxyribonucleic acid). The lectures will investigate DNA structure and function, including transcription and translation into proteins, normal protein function and chromosome structure. This will be followed by discussions on how changes in DNA (mutations) disrupt the normal biological patterns and lead to a variety of disease phenotypes. Patterns of inheritance, principles of genetics, and methods of genetic testing will also be explored. Specific examples of human disease will illustrate these points.

Unit 2

Goals of this segment:

In Segment B, the focus is on biological processes at the cellular level. Information regarding cell to cell interactions, intracellular control mechanisms, and cellular organelles will be covered. The function and control of enzymes will also be discussed, including in depth analysis of specific biological pathways such as glycolysis, electron transport, oxidative phosphorylation and carbohydrate metabolism. An overview of how these processes are important in developmental pathways is also provided.

One of the unique features of Segment B are the conferences. Small groups of students will meet together with a facilitator to discuss important aspects of molecular, cellular, and genetic issues for a group of selected diseases. By investigating the molecular foundations of these disorders, it is hoped the students will gain a better appreciation of the diversity and intricacy of clinical problems and medical practice.

Unit 9

Goals of this segment:

Segment C will examine metabolism and nutrition. Key areas of discussion include lipids, amino acids, vitamins, minerals, and cofactors. Building on a basic understanding of these topics, clinical examples of obesity, alcoholism, and atherosclerosis will provide a more detailed understanding of how the individual pieces function together as essential elements of human biology.

To further demonstrate the importance of these elements, Segment C incorporates four clinical problem sessions to link didactic material to case studies.