MSII Schedule

MLC II : Pathophysiologic Mechanisms of Disease (2009-2010)

Aug 24 Sepsis in-class exercise
  26 Read: Self-injection of endotoxin
  28 Read: Acute reversible myocardial depression associated with sepsis
Aug 31 Read: Case 13-2009
Sept 2 Read: Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease
  4 Read: Practical approaches to the patient with severe sepsis: Illustrative case histories
Sept 9 Read: Case 11-2009
  11 Read: Surviving sepsis - Practice guidelines, marketing campaigns, and Eli Lilly
Read: Severe sepsis and therapy with activated protein C
Sept 14 Read: An unintended consequence
  16 Read: Sepsis: From bench to bedside
Sepsis hypotheses due; end-of-unit quiz ("closed book quiz")

Sept 23 In-class exercise
  25 Read: Case 25-2009
Sept 30 Read: Case 38-2008
Oct 2 Hypothesis due
Oct 5 Read: Case 39-2008
  7 In-class exercise
  9 Hypothesis due
Oct 14 Read: Genetic variation & susceptibility to infection: the red cell & malaria

Oct 21 Read: Lung pathophysiology mini-cases set #1
  23 Read: Woman With Respiratory Distress and Alveolar Hemorrhage After Transfusion
Oct 26 Read: Natural History of Fatal Childhood Asthma- Case from Isle of Wright Birth Cohort
  28 Read: Lung pathophysiology mini-cases set #2
  30 Read: Asthma pathophysiology
General asthma hypothesis due
Nov 2 Read: Case 32-2001
  4 Read: Lung pathophysiology mini-cases set #3
  4 Optional extra credit exercise
Case Report: DKA on Mt. Rainier
  6  
Nov 9 Assignment: Rheumatology workbook: mini-cases part 1
  11 Assignment: Rheumatology workbook: mini-cases part 2

Nov 18 Read: Case 37-2007
  20 Hypothesis due
Nov 23 Read: Vasculitis primer
Assignment: Vasculitis mini-cases part 1
  25 Assignment: Vasculitis mini-cases part 2
Nov 30 Read: Case 22-2004
Dec 2 Read: Cardiovascular pathophysiology mini-cases
  4 Hypothesis due
Dec 7 Read: Case 29-2002
  9 Read: Heart failure in aortic stenosis
Read: Cardiovascular pathophysiology mini-case
  11 Read: Valvular disorders handout
Hypothesis due
Dec 14 End-of-unit quiz ("closed book quiz")

Jan 4 Read: Case 7-2008
  6 Handout: Mechanisms of edema
  8 Assignment: Mini-cases set #1 due
  8 General hypothesis on nephrotic syndrome
Jan 11 Read: Variations on a theme
  13 Assignment: Mini-cases set #2 due
  15  
Jan 19 Assignment: Mini-cases set #3 due
  20 Read: When past is prologue
  22 "Halfway to Renal Heaven" mid-unit quiz
  22 Hypothesis due
Jan 25 Read: Case 23-2009
  27 Assignment: Mini-cases set #4 due
  29
Feb 1 Read: Primary aldosteronism and preclinical Cushing's syndrome in a patient with double adenomas of right adrenal gland
  3 Renal review: In-class "closed book" mock examination
  3 Discussion of mock examination

Feb 10 Read: Case 12-2008
  12 In-class exercise
Feb 15 Read: Case 8-2009
  17 General hypothesis on normal pregnancy physiology
  19 General hypothesis on eclampsia
Feb 22 Read: Improvement in insulin sensitivity followed by ovulation and pregnancy in a woman with polycystic ovary syndrome who was treated with rosiglitazone
Read: Clinical presentation of PCOS following development of an insulinoma
  24 In-class exercise
  26 General hypothesis on PCOS
March 1 Read: Kiss of Death
Read: Endothelin-receptor antagonist/N-acetylcysteine combination in type 1 hepatorenal syndrome
  3 In-class exercise
  5 General hypothesis on hepatorenal syndrome
March 8 Gastroenterology review ("closed book" mock examination)
  10 Read: "State of Mind of the Olympic Athlete" mini-cases

March 22 Read: A 24-Year-Old Woman With Intractable Seizures
  24 Discussion: Surgical Treatment for Epilepsy
  26 In-class exercise
March 29 Read: Case 26-2008
  31 In-class exercise
April 2 Read: Not a Basic Case
April 5 Read: Case 40-2008
  9 Read: Ophthalmology mini-cases
April 12 Read: Case 14-2008
  14 Read: The Depressing News About Antidepressants
Read: Antidepressant Drug Effects and Depression Severity
  16 In-class exercise
April 19 Read: Case 20-2008
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