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MSII Schedule
MLC II : Pathophysiologic Mechanisms of Disease (2008-2009)
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| Aug |
25 |
Introduction; Sepsis in-class exercise |
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27 |
Read: Harrison's Chapter 265 on sepsis;
Compare hypovolemic, cardiogenic and distributive shock (Harrison's Table 266-2)
Watch video |
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29 |
Handouts: Organ system dysfunction & clinical enzymology and acute-phase phenomena |
| Sept |
3 |
Read: Self-injection of endotoxin & personal experience w/ MODS and SIRS
Watch videos
Read: Lange Chapter 4: Infectious Diseases
Submit assignment |
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5 |
Read & watch video: 100 years of sepsis
Read & watch video: Surviving Sepsis Campaign & Eli Lilly , APC therapy
Handout: Treatment of sepsis |
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8 |
Read: Case 13-1996 (pneumonia and sepsis) |
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10 |
Acid-base in-class exercise |
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12 |
Hypothesis due |
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15 |
Read: Case 21-2008 (chronic granulomatous disease) |
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17 |
Read: Lange Chapter 3: Disorders of the Immune System |
| Sept |
24 |
Read: No respector of age |
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26 |
Assignment: Rheumatology mini-cases |
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29 |
Read: Case 30-2004 |
| Oct |
1 |
Read: Protecting against autoimmunity |
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3 |
Hypothesis due |
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6 |
Read: Case 33-2007 |
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10 |
Hypothesis due |
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15 |
Read: Lange Chapter 6: Blood |
| Oct |
22 |
Read: Case 13-2008 |
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24 |
Read: Malignant lymphomas in autoimmunity and inflammation: A review of risks, risk factors, and lymphoma characteristics
Hypothesis due |
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27 |
Read: Case 32-2007 |
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29 |
Read: Cancer Mini-Cases Set #1 |
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31 |
Read: Cancer Mini-Cases Set #2 |
| Nov |
3 |
Read: Metastatic Melanoma Package |
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7 |
Read: Cancer Immunology |
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10 |
Read: Lange Chapter 5: Neoplasia |
| Nov |
17 |
Read: Case 36-2007 |
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19 |
Read: Constrictive pericarditis, Electrical alternans, Pulsus paradoxus |
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21 |
Hypothesis due |
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24 |
Assignment: Vasculitis outlines |
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26-28 |
Assignment: Vasculitis mini-cases |
| Dec |
1 |
Read: Case 9-2005 |
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5 |
Hypothesis due |
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8 |
Read: Case 34-2006 |
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12 |
Assignment: Valvular disease handout ; take-home quiz |
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15 |
Read: Lange Chapter 10: Heart; 11: Blood Vessels |
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16 |
Read: Lange Chapter 9: Lung |
| Jan |
5 |
Read: Case 36-2003 |
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7 |
Assignment: Nephrotic syndrome |
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9 |
Assignment: Online case modules D & F |
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12 |
Read: Case 40-2004 |
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14 |
Assignment: Online case modules B & C |
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16 |
Assignment: Online case modules I & M |
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21 |
Read: A case of hyponatremia caused by central hypocortisolism |
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23 |
Read: Lange Chapter 17: Parathyroid; Chapter 18: Diabetes; Chapter 19: Pituitary; Chapter 20: Thyroid; Chapter 21: Adrenal |
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26 |
Read: Case 2-2008 |
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27 |
Read: Proteinuria and Immunity - An Overstated Relationship?
Assignment: Online case module P |
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28 |
Assignment: Online case modules N & O |
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30 |
Assignment: Online transplant case modules A, B, C, D & E |
| Feb |
2 |
Assignment: Renal involvement in systemic disease
Read: A case of lupus nephritis |
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4 |
Read: Lange Chapter 16: Kidney
Renal review: Mock examination
Discussion of mock examination |
| Feb |
11 |
Read: A 27 yo woman with a diagnosis of PCOS |
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13 |
Read: Metformin for the treatment of the polycystic ovary syndrome |
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16 |
Read: Needle in a Haystack |
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18 |
In-class exercise |
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20 |
Read: Severe acute pancreatitis |
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23 |
Read: A Stain in Time |
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25 |
In-class exercise |
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27 |
Read: The FDA and the Case Against Ketek
Read: Severe Hepatotoxicity of Telithromycin |
| Mar |
2 |
Read: Case 38-2005 |
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4 |
Watch video of case discussion
Watch video pertaining to molecular mechanisms
Review Powerpoint pertaining to molecular mechanisms
Handout: Molecular mechanisms of preeclampsia
Handout: Physiologic changes in normal pregnancy and in preeclampsia |
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6 |
Read: The two stage model of preeclampsia: Variations on the theme
Assignment: Hypotheses on normal pregnancy and preeclampsia |
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9 |
Read: Lange Chapter 13: GI; 14: Liver; 15: Exocrine pancreas |
| Mar |
23 |
Read: Case 22-2006 |
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25 |
In-class exercise |
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27 |
In-class exercise |
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30 |
Read: A 74 year-old man with memory loss and neuropathy |
| April |
1 |
In-class exercise |
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3 |
Read: Neurobiological aspects of psychotherapy |
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6 |
Read: Leg weakness in a 66 year-old woman |
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8 |
In-class exercise |
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10 |
In-class exercise |
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13 |
Read: Woman with Brugada syndrome and epilepsy |
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15 |
Read: Optic neuritis |
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17 |
Read: Pharmacokinetics and pharmacodynamics of quetiapine in a patient with a massive overdose |
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20 |
Read: Lange Chapter 7: Nervous System |
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