MSII Schedule

MLC II : Pathophysiologic Mechanisms of Disease (2008-2009)

Aug 25 Introduction; Sepsis in-class exercise
  27 Read: Harrison's Chapter 265 on sepsis;
Compare hypovolemic, cardiogenic and distributive shock (Harrison's Table 266-2)
Watch video
  29 Handouts: Organ system dysfunction & clinical enzymology and acute-phase phenomena
Sept 3 Read: Self-injection of endotoxin & personal experience w/ MODS and SIRS
Watch videos
Read: Lange Chapter 4: Infectious Diseases
Submit
assignment
  5 Read & watch video: 100 years of sepsis                               
Read & watch video: Surviving Sepsis Campaign & Eli Lilly , APC therapy   
Handout: Treatment of sepsis
  8 Read: Case 13-1996 (pneumonia and sepsis)
  10 Acid-base in-class exercise
  12 Hypothesis due
  15 Read: Case 21-2008 (chronic granulomatous disease)
  17 Read: Lange Chapter 3: Disorders of the Immune System

Sept 24 Read: No respector of age
  26 Assignment: Rheumatology mini-cases
  29 Read: Case 30-2004
Oct 1 Read: Protecting against autoimmunity
  3 Hypothesis due
  6 Read: Case 33-2007
  10 Hypothesis due
  15 Read: Lange Chapter 6: Blood

Oct 22 Read: Case 13-2008
  24 Read: Malignant lymphomas in autoimmunity and inflammation: A review of risks, risk factors, and lymphoma characteristics
Hypothesis due
  27 Read: Case 32-2007
  29 Read: Cancer Mini-Cases Set #1
  31 Read: Cancer Mini-Cases Set #2
Nov 3 Read: Metastatic Melanoma Package
  7 Read: Cancer Immunology
  10 Read: Lange Chapter 5: Neoplasia

Nov 17 Read: Case 36-2007
  19 Read: Constrictive pericarditis, Electrical alternans, Pulsus paradoxus
  21 Hypothesis due
  24 Assignment: Vasculitis outlines
  26-28 Assignment: Vasculitis mini-cases
Dec 1 Read: Case 9-2005
  5 Hypothesis due
  8 Read: Case 34-2006
  12 Assignment: Valvular disease handout ; take-home quiz
  15 Read: Lange Chapter 10: Heart; 11: Blood Vessels
  16 Read: Lange Chapter 9: Lung

Jan 5 Read: Case 36-2003
  7 Assignment: Nephrotic syndrome
  9 Assignment: Online case modules D & F
  12 Read: Case 40-2004
  14 Assignment: Online case modules B & C
  16 Assignment: Online case modules I & M
  21 Read: A case of hyponatremia caused by central hypocortisolism
  23 Read: Lange Chapter 17: Parathyroid; Chapter 18: Diabetes; Chapter 19: Pituitary; Chapter 20: Thyroid; Chapter 21: Adrenal
  26 Read: Case 2-2008
  27 Read: Proteinuria and Immunity - An Overstated Relationship?
Assignment: Online case module P
  28 Assignment: Online case modules N & O
  30 Assignment: Online transplant case modules A, B, C, D & E
Feb 2 Assignment: Renal involvement in systemic disease
Read: A case of lupus nephritis
  4 Read: Lange Chapter 16: Kidney
Renal review: Mock examination
Discussion of mock examination

Feb 11 Read: A 27 yo woman with a diagnosis of PCOS
  13 Read: Metformin for the treatment of the polycystic ovary syndrome
  16 Read: Needle in a Haystack
  18 In-class exercise
  20 Read: Severe acute pancreatitis
  23 Read: A Stain in Time
  25 In-class exercise
  27 Read: The FDA and the Case Against Ketek
Read: Severe Hepatotoxicity of Telithromycin
Mar 2 Read: Case 38-2005
  4 Watch video of case discussion
Watch video pertaining to molecular mechanisms
Review Powerpoint pertaining to molecular mechanisms
Handout: Molecular mechanisms of preeclampsia
Handout: Physiologic changes in normal pregnancy and in preeclampsia
  6 Read: The two stage model of preeclampsia: Variations on the theme
Assignment: Hypotheses on normal pregnancy and preeclampsia
  9 Read: Lange Chapter 13: GI; 14: Liver; 15: Exocrine pancreas

Mar 23 Read: Case 22-2006
  25 In-class exercise
  27 In-class exercise
  30 Read: A 74 year-old man with memory loss and neuropathy
April 1 In-class exercise
  3 Read: Neurobiological aspects of psychotherapy
  6 Read: Leg weakness in a 66 year-old woman
  8 In-class exercise
  10 In-class exercise
  13 Read: Woman with Brugada syndrome and epilepsy
  15 Read: Optic neuritis
  17 Read: Pharmacokinetics and pharmacodynamics of quetiapine in a patient with a massive overdose
  20 Read: Lange Chapter 7: Nervous System
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