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MSII Schedule
MLC II : Pathophysiologic Mechanisms of Disease (2007-2008)
Case readings in BLUE, supplemental articles in ORANGE
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| Aug |
27 |
Introduction; Sepsis mini-case |
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29 |
Shock and multiple-organ dysfunction after self-administration of salmonella endotoxin [NEJM 328(20): 1457, 1993]; A personal experience with SIRS and MODS [Crit Care Med 24(8): 1417, 1996] |
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31 |
Assignment: Sepsis terminology and organ system dysfunction |
| Sept |
5* |
Case 9-2004 [NEJM 350(12): 1236, 2004] |
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7
| Pandemic flu issues:
H5N1 Influenza - continuing evolution and spread [NEJM 355(21): 2174, 2006]; Human H5N1 Influenza [NEJM 356(13): 1375, 2007]; Preparing for the next pandemic [NEJM 352(18): 1839, 2005] |
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10 |
The last 100 years of sepsis [Am J Respir Crit Care Med 173: 256, 2006]; Assignment: Treatment of sepsis |
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12 |
Surviving sepsis - practice guidelines, marketing campaigns, and Eli Lilly [NEJM 355: 1640, 2006]; Severe sepsis and therapy with activated protein C [NEJM 353: 1398, 2005] |
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14 |
Sepsis hypothesis due |
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17 |
Ring around the diagnosis [NEJM 354(18): 1937, 2006] |
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19 |
Hypothesis due |
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24 |
Unit I Examination |
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26* |
Rheumatologic disease workbook: mini-cases A-B (+ assignment: outline specified diseases) |
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28 |
Rheumatologic disease workbook: mini-cases C-D (+ assignment: outline specified diseases) |
| Oct |
1 |
Case 19-2007 [NEJM 356(25): 2631, 2007] |
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3 |
Rheumatologic disease workbook: mini-cases E-F |
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5 |
Hypothesis due |
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10* |
Case 15-2006 [NEJM 354(20): 2166, 2006] |
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12 |
Hypothesis due |
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15 |
Special cure [NEJM 351(19): 1997, 2004] |
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17 |
Hypothesis due |
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22 |
Unit II Examination |
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24* |
Cancer mini-cases: set #1 |
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26 |
Cancer mini-cases: set #2 |
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29 |
Case 4-2007 [NEJM 356(6): 612, 2007] |
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31 |
A 42 year-old woman with breast cancer [Oncology 17(5): 614, 2003] |
| Nov |
2 |
Hypothesis due |
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5 |
Case 29-2006 [NEJM 355(12): 1263, 2006] |
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7 |
Cancer mini-cases: set #3 |
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9 |
Hypothesis due |
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12 |
Case 40-2006 [NEJM 355(26): 2772, 2006] |
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16 |
Unit III Examination |
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19 |
Vasculitis assignment and notes |
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21 |
Saved by a test result [NEJM 330(5): 343, 1994] |
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26 |
Undercover and overlooked [NEJM 351(10): 1014, 2004] |
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28 |
Pericardial images mini-cases: Constrictive pericarditis, Electrical alternans, Pulsus paradoxus |
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30 |
Hypothesis due |
| Dec |
3 |
Case 15-2007 [NEJM 356(20): 2083, 2007] |
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5 |
Gas exchange, expiratory flow obstruction and the clinical spectrum of asthma [Eur Respir J 9:1278, 1996]; Asthma mini-case |
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7 |
Hypothesis due |
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10 |
Search for the complication [NEJM 354(9): 957, 2006] |
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12 |
Atrial fibrillation readings (Jalife package + NEJM catheter ablation study) |
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14 |
Hypothesis due |
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21 |
Unit IV Examination |
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| Jan |
7 |
Case 3-2000 [NEJM 342(4): 264, 2000] |
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9 |
Handout: Mechanisms of edema |
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11 |
Central role of vasopressin in sodium/water retention in hypo- and hypervolemic nephrotic patients: A unifying hypothesis [J Nephrol 17(5): 653, 2004]; Assignment: Nephrotic syndrome |
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14 |
Case 36-2006 [NEJM 355(21): 2237, 2006] |
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16 |
Complete module Case F - see "Case Studies" tab |
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18 |
Assignment: Disease outlines; Assignment: Case 36-2006 questions |
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22 |
(Complete module Cases B & G - see "Case Studies" tab) |
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23* |
Case 11-2004 [NEJM 354(26): 2803, 2004] |
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25 |
(Complete module Cases C, I & M - see "Case Studies" tab) |
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28 |
Case 31-2007 [NEJM 355(23): 2468, 2007] |
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29 |
(Complete module Case H - see "Case Studies" tab) |
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30 |
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| Feb |
1 |
Systemic disease mini-cases |
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4 |
Complete module Case 4 |
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5 |
(Read patient synposis "The One Patient Renal Curriculum") |
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6 |
Renal review: mock examination |
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11 |
Unit V Examination |
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13* |
Case 35-2007 [NEJM 357(20): 2068, 2007] |
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15 |
Hypothesis due |
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18 |
Case 31-2006 [NEJM 355(15): 1593, 2006] |
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20 |
Outlines: Polycystic Ovary Syndrome and Nonalcoholic Steatohepatitis |
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22 |
Bariatric Surgery for Morbid Obesity [NEJM 356(21): 2176, 2007]; Missing Link [NEJM 357(8): 818, 2007] |
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25 |
A hypertensive emergency in an obese young woman [Cleve Clin J Med 73(2): 110, 2006]; Related handout |
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27 |
Molecular mechanisms of preeclampsia [Microvascular Research 75:1, 2008]; Related handout |
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29 |
Assignment: Normal pregnancy and preeclampsia outlines and case hypothesis |
March
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3
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Concurrent IVF and spontaneous conception resulting in a quadruplet pregnancy [Human Reprod 16(11): 2324, 2001] |
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7 |
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14 |
Unit VI Examination |
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24 |
"Enterovirus Infection in Taiwan" Package |
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26
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The 1998 Enterovirus 71 Outbreak in Taiwan: Pathogenesis and Management [Clin Infect Dis 34(Suppl 2): S52, 2002] |
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28 |
Hypothesis due |
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31 |
Case 35-2002 [NEJM 347(20): 1604, 2002] |
| April |
2 |
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4 |
Hypothesis due |
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7 |
Case 24-2000 [NEJM 343(6): 420, 2000] |
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9 |
Tales from the Temporal Lobes [NEJM 352(2): 119, 2005] |
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11 |
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14 |
Case 16-2002 [NEJM 346(21): 1651, 2002] |
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16 |
Thrombosis of the Cerebral Veins and Sinuses [NEJM 352(17): 1791, 2005] |
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18 |
Wrap-up part 1 |
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21 |
Wrap-up part 2 |
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25 |
Unit VII Examination |
| May |
9 |
Make-up case #1: Case 12-1995 [NEJM 332(16): 1083, 1995]
Make-up case #2: Case 35-2001 [NEJM 345(20: 1483, 2001] |
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