MSII Schedule

MLC II : Pathophysiologic Mechanisms of Disease (2006-2007)

Case readings in BLUE, supplemental articles in ORANGE
     
Aug 28 Introduction to course
  31 A jaundiced eye [NEJM 354(14): 1516, 2006]
Sept 1 Hypothesis Due
  5 Case 17-1999 [NEJM 340(23):1819, 1999] 
  7  
  8 Handout: Organ System Dysfunction
 

11

Shock and multiple-organ dysfunction after self-administration of salmonella endotoxin [NEJM 328(20): 1457, 1993]; Handout: Effects of Endotoxin in Humans
  14  
  15 Handout: Why Sepsis Trials Fail
  18 Hypothesis Due
  21  
  25 Unit I Examination: Inflammation/hemodynamics
  26 Mini-cases: Constrictive pericarditis, Electrical alternans, Pulsus paradoxus
  28 Of nicks and time [NEJM 345(5): 359, 2001]
  29 Hypothesis Due
Oct 3 A perfect storm [NEJM 353(18): 1956, 2005]
  5
  6 Hypothesis Due
  10 Case 14-2006 [NEJM 354(19): 2047, 2006]
  12 Hepcidin: we always knew you were there [Blood 105(10): 3760, 2005]; Venous thromboembolism and hypercoagulability in splenectomized patients with thalassaemia intermedia [Br J Haematol 111(2): 467, 2000]
  13 Hypothesis Due
  16 The domino principle [NEJM 335(5): 340, 1996]
  19 Hypothesis Due
  23 Unit II Examination: Hematology/immunology
  24 Mini-cases: Metabolic derangements in cancer
  26 Case 8-2006 [NEJM 354(11): 1178, 2006]
  27  
  30 Hypothesis Due

Nov

2 A mutation conferring resistance to imatinib at the time of diagnosis of chronic myelogenous leukemia [NEJM 348(22): 2265, 2003]
  3 Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias [NEJM 354(24: 2531, 2006]
  6 Easy to see but hard to find [NEJM 348(1): 59, 2003]
  9
  10 Hypothesis Due
  17 Unit III Examination: Cancer
  20 Case 30-2002 [NEJM 347(13): 1009, 2002]
  27 Case 17-2005 [NEJM 352(23): 2425, 2005]
  30  
Dec 1 Hypothesis Due
  4 Studying the classics [NEJM 333(10): 648, 1995]
  7 Mini-cases:  Mitral stenosis, Mitral regurgitation
  8 Hypothesis Due
  11 Search for the complication [NEJM 354(9): 957, 2006]
  15 Catheter Ablation of Chronic Atrial Fibrillation - The Gap between Promise and Practice [NEJM 354(9): 967, 2006]; Circumferential Pulmonary-Vein Ablation for Chronic Atrial Fibrillation [NEJM 354(9): 934, 2006]; Rotors and Spiral Waves in Atrial Fibrillation[J Cardiovasc Electrophysiol 14: 776, 2003]
  18 Hypothesis Due
  22 Unit IV Examination: Cardiovascular and pulmonary
     
Jan 4 Case 15-2005 [NEJM 352(20): 2111, 2005]
  5  
  8 Hypothesis Due
  11 Case 7-2005 [NEJM 352(10): 1025, 2005]
  12 Hypothesis Due
  16 Case 28-2005 [NEJM 353(11): 1148, 2005]
  16 Electrolyte session (case module questions due before start of class)
  19 Hypothesis Due
  22 A fractured diagnosis [NEJM 353(5): 509, 2005]
  25 Electrolyte session (case module questions due before start of class)
  26 Hypothesis Due
  29 Case 6-2004 [NEJM 350(8): 810, 2004]
Feb 1  
  1 Electrolyte session (case module questions due before start of class)
  2  
  9 Unit V Examination: Renal/Endocrine
  12 Case 38-2005 [NEJM 353(24:) 2590, 2005]
  15 Latest advances in understanding preeclampsia [Science 308 (5728): 1592, 2005]
  16 Hypothesis Due
  19 Case 1-1997 [NEJM 336(2): 118, 1997]
  22  
  23 Hypothesis Due
  26 Case 3-2005 [NEJM 352(4): 393, 2005]
March 2 Hypothesis Due
 

5

Improvement in insulin sensitivity followed by ovulation and pregnancy in a woman with polycystic ovary syndrome who was treated with rosiglitazone [Fertil Steril 76(5): 1057, 2001]; Clinical presentation of PCOS following development of an insulinoma [Human Reproduction 15(1): 86, 2000]
  8 Beta-cell function: a key pathological determinant in polycystic ovary syndrome [J Clin Endocrinol Metab 90(1):310, 2005]
  9 Hypothesis Due
  16 Unit VI Examination: Gastroenterology/Gyn
  26 Comparing cognitive behavior therapy, interpersonal psychotherapy, and psychodynamic psychotherapy [Am J Psychiatry 161(9): 1567, 2004]
  29 Neurobiological aspects of psychotherapy [J Psychother Pract Res 8(2): 103, 1999]
  30  
April 2 Case 39-2006 [NEJM 355(25):2678, 2006]
  5  
  6  
  9
Forgotten frontal lobe syndrome or "executive dysfunction syndrome" [Psychosomatics 45(3): 247, 2004]
  12 Frontal–subcortical neuronal circuits and clinical neuropsychiatry: An update [J Psychosom Res 53(2): 647, 2002]
  13 Lessons from Neuropsychiatry [J Neuropsychiatry Clin Neurosci 18(4): 445, 2006]
  16 A 48-Year-Old Man With Temporal Lobe Epilepsy and Psychiatric Illness [JAMA 290(3): 381, 2003]
  19 Tales from the temporal lobe [NEJM 352(2):119, 2005]
  20  
  24 Unit VII Examination: Neuro
May 8 Make-up case #1: Needle in a haystack [NEJM 354(1): 68, 2006]
Make-up case #2: A window of opportunity [NEJM 349(19): 1848, 2003]



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