| |
|
|
| Aug |
29 |
Introduction to course |
| |
31 |
Clear as Mud [NEJM 352(18): 1914, 2005] |
| Sept |
2 |
Hypothesis Due |
| |
7 |
Case 13-1996 [NEJM 334(17):1116, 1996] |
| |
9 |
Handout: Effects of endotoxin in humans |
| |
12 |
Shock and multiple-organ dysfunction after self-administration of salmonella endotoxin [NEJM 328(20): 1457, 1993] |
| |
14 |
|
| |
16 |
Handout: Organ system dysfunction in sepsis |
| |
19 |
Handout: Why sepsis trials fail |
| |
21 |
Hypothesis Due |
| |
23 |
Study Day |
| |
26 |
Unit I Examination: Inflammation/hemodynamics |
| |
28 |
A broken heart [NEJM 334(5): 319, 1996] |
| |
30 |
Handout: Cardiac tamponade and pulsus paradoxus; Hypothesis Due |
| Oct |
3 |
Through thick and thin [NEJM 338(23):1684, 1998] |
| |
5 |
|
| |
7 |
Handout: Pathogenesis of pulmonary embolism; Hypothesis Due |
| |
12 |
A leading question [NEJM 339(12): 827, 1998] |
| |
14 |
Hypothesis Due |
| |
17 |
The domino principle [NEJM 335(5): 340, 1996] |
| |
19 |
Hypothesis Due |
| |
21 |
Study Day |
| |
24 |
Unit II Examination: Hematology/immunology |
| |
25 |
Anti-Ma 2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer [J Neurol Neurosurg Psychiatry 74(9): 1332, 2003] |
| |
26 |
Handout: Paraneoplastic limbic encaphalitis |
| |
28 |
Shedding light on immunotherapy for cancer [NEJM 350(14): 1461, 2004]; Hypothesis Due |
| |
31 |
Case 28-1997 [NEJM 337(11): 770, 1997] |
| Nov |
2 |
A growing network of cancer-susceptibility genes [NEJM 348(19): 1917, 2003] |
| |
4 |
Hypothesis Due |
| |
7
|
A case of metastatic breast cancer with outgrowth of Her2-negative cells after eradication of Her2-positive cells byhumanized anti-Her2 monoclonal antibody (Trastuzumab) combined with docetaxel [Human Pathol 35(3):379, 2004] |
| |
9
|
Breast Cancer — Loss of PTEN Predicts Resistance to Treatment [NEJM 351(22): 2337, 2004
Handout: ACTR/AIB1 and Breast Cancer; Hypothesis Due |
| |
11
|
Two metachronous tumors in the radiotherapy fields of a patient with Li-Fraumeni syndrome [Int J Cancer 96(4):238, 2001]
Oncogenic pathways in hereditary and sporadic breast cancer [Maturitas 49:34, 2004]; Hypothesis Due |
| |
16 |
Study Day |
| |
18 |
Unit III Examination: Cancer |
| |
21 |
Rituximab induces remission in refractory HCV associated cryoglobulinemic vasculitis [Ann Rheum Dis 62: 1230, 2003]; Handout: Biology of Hepatitis C virus |
| |
23 |
Hypothesis Due |
| |
28 |
A Perfect Storm [NEJM 353(18): 1956, 2005] |
| |
30 |
|
| Dec |
2 |
Hypothesis Due |
| |
5 |
Case 9-2004 [NEJM 350(12): 1236, 2004] |
| |
7 |
Influenza virus still surprises [Curr Opin Microbiol 5: 414, 2002] |
| |
9 |
Hypothesis Due |
| |
12 |
Case 15-2005 [NEJM 352(20): 2111, 2005] |
| |
14 |
Handout: Mechanisms of edema |
| |
16 |
Handout: Amyloidosis; Hypothesis Due |
| |
21 |
Unit IV Examination: Cardiovascular and pulmonary |
| |
|
|
| Jan |
9 |
Importance of a name [NEJM 340(18): 1418, 1999] |
| |
11 |
Mitochondrial dysfunction and Type 2 diabetes [Science 307: 384, 2005]
Handout: Insulin Resistance |
| |
13 |
Hypothesis Due |
| |
17 |
Case 34-2000 [NEJM 343(19): 1399, 2000] |
| |
18 |
|
| |
20 |
Hypothesis Due |
| |
23 |
A fractured diagnosis [NEJM 353(5): 509, 2005] |
| |
25 |
Assignment: Renal involvement in connective tissue diseases and tubular syndromes |
| |
27 |
Handout: Acid-Base; Hypothesis Due |
| |
30 |
Case 4-2002 [NEJM 346(5): 353, 2002] |
| Feb |
1 |
|
| |
3 |
Hypothesis Due |
| |
6 |
Renal Review: Web Modules I |
| |
7 |
Renal Review: Web Modules II |
| |
8 |
Study Day |
| |
10 |
Study Day |
| |
13 |
Unit V Examination: Renal/Endocrine |
| |
14 |
A girl with cystic fibrosis and failure to thrive [J Pediatr 143: 115, 2003] |
| |
15 |
|
| |
17 |
Handout: Normal and abnormal (Cystic Fibrosis) physiology; Hypothesis Due |
| |
20 |
Clinical correlates of starvation in man [Mo Med 83(1): 23, 1986] |
| |
22 |
Cachexia in Cancer - Zeroing in on Myosin [NEJM 351: 2124, 2004]
Handout: Proteasome expression and resting energy expenditure |
| |
24 |
Handout: Physiologic changes in normal pregnancy and in preeclampsia |
| |
27 |
Case 30-1998 [NEJM 339(13): 906, 1998] |
| March |
1 |
|
| |
3 |
Latest Advances in Understanding Preeclampsia [Science 308: 1592, 2005]
Preeclampsia - Searching for the Cause [NEJM 350(7): 641, 2004]; Hypothesis Due |
| |
6 |
Case 6-2001 [NEJM 344(8): 591, 2001] |
| |
8 |
Assignment: MDMA interaction with neurotransmitter systems in CNS |
| |
10 |
Handout: Mechanisms of liver injury; Hypothesis Due |
| |
13 |
GI/Liver Review: Ulcerative colitis and Crohn’s disease |
| |
14 |
GI/Liver Review: Case summaries |
| |
17 |
Unit VI Examination: Gastroenterology/Gyn |
| |
27 |
Case 5-2004 [NEJM 350(7): 707, 2004] |
| |
29 |
Handout: Mechanisms of ischemia-reperfusion injury |
| |
31
|
Stroke and Neurovascular Protection [N Engl J Med 354: 553, 2006]; NXY-059 for Acute Ischemic Stroke [N Engl J Med 354: 588, 2006]; Handout: Toxic oxygen metabolics and proposed mechanism of free radical damage in stroke; Hypothesis Due |
| April |
3 |
Comparing cognitive behavior therapy,interpersonal psychotherapy, &psychodynamic therapy [Am J Psychiatry 161:9, 2004] |
| |
5 |
|
| |
7 |
Neurotrophic Effects of Electroconvulsive Therapy: A Proton Magnetic Resonance Study of the Left Amygdalar Region in Patients with Treatment-Resistant Depression [Neuropsychopharmacology (2003) 28, 720–725] |
| |
11 |
A 48-year old man with temporal lobe epilepsy and psychiatric illness [JAMA 290(3): 381, 2003] |
| |
12 |
|
| |
14 |
|
| |
18 |
Ventral occipital lesions impair object recognition but not object-directed grasping: an fMRI study [Brain 126(Pt 11):2463-75, 2003] |
| |
19 |
|
| |
21 |
|
| |
24 |
Extra Credit Case |
| |
25 |
Extra Credit Crossword |
| |
28 |
Unit VII Examination: Neuro |
| May |
12 |
Make-Up Quiz for Eligible Students |
