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SUNY Upstate Medical university Case Study

MLC III: Current Biomedical Research (2008-2009)

Class meets on Tuesdays from 5:00 - 7:00 p.m. in Room 103 Weiskotten.


The main focus for each session is a report of clinical or translational research, oftentimes accompanied by a perspective piece (editorial, mini-review) and a report of some concrete event (patient case or news article) that makes the reason for studying the subject more obvious or compelling.

Each session will feature an in-class quiz and short written assignment addressing the course objectives given below.

  • Knowledge of the basic science and clinical issues relevant to the readings.
  • Ability to assess and critique the research presented.
  • Ability to translate the research into lay language appropriate for communication with patients
  • Ability to appropriately apply the findings to clinical problems.
  • Ability to suggest further research questions stemming from the study results.
  • A scientific attitude and knowledge of the scientific method.
  • Awareness of ethical issues in scientific investigation.
Jul
15
Hematology/Oncology: Cancer Treatment Breakthroughs -S. Grethlein

Perspective: Panitumumab the first fully human monoclonal antibody: from the bench to the clinic [Anti-Cancer Drugs 18: 7, 2007]
Trial: Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer [J Clin Oncol 26: 1626, 2008]
22
Neurosurgery: Deep Brain Stimulation - J. Holsapple

Perspective: Scientists Probe Deep Brain Stimulation [JAMA 298(19): 2249, 2007]
Study #1 : A Randomized Trial of Deep-Brain Stimulation for Parkinson’s Disease [NEJM 355(9): 896, 2006]
Study #2: Behavioural improvements with thalamic stimulation after severe traumatic brain injury [Nature 448: 600, 2007]
29
Infectious Disease/Global Health: Dengue Hemorrhagic Fever – T. Endy

Commentary: Dengue and Hemorrhagic Fever – A Potential Threat to Public Health in the United States [JAMA 299(2): 214, 2008]
Perspective: Hunt for Dengue Vaccine Heats Up As the Disease Burden Grows [Science 317: 1494, 2007]
Study: Epidemic Dengue and Dengue Hemorrhagic Fever at the Texas-Mexico Border: Results of a Household-based Seroepidemiologic Survey, December 2005 [Am J Trop Med Hyg 78(3): 364, 2008]
Aug
5
Cardiology: The Great Debate in Preventive Cardiology - R. Carhart

Research: Effect of Lower Targets for Blood Pressure and LDL Cholesterol on Atherosclerosis in Diabetes: The SANDS Randomized Trial [JAMA 299(14): 1678, 2008]
Editorial: The Great Debate of 2008—How Low to Go in Preventive Cardiology? [JAMA 299(14): 1718, 2008]
12
Transplant Surgery: Tolerance - A. Friedman

Research: HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression [NEJM 358(4): 353, 2008]
Editorial: Immunosuppressive Therapy and Tolerance of Organ Allografts [NEJM 358(4): 407, 2008]
19
Surgery: Surgical Treatment of Type 2 Diabetes - P. Cunningham

PerspectiveIs Type 2 Diabetes an Operable Intestinal Disease? [Diabetes Care 31(Suppl 2): S290, 2008]
Study: Adjustable Gastric Banding and Conventional Therapy for Type 2 Diabetes [JAMA 299(3):316, 2008]
Editorial: Gastrointestinal Surgery as a Treatment for Diabetes [JAMA 299(3): 341, 2008]

26
Family Medicine/Primary Care: Communicating Evidence to Patients – J. Epling

Editorial: Understanding Uncertainty [Ann Fam Med 6(3): 196, 2008]
Study 1: Absolute Cardiovascular Disease Risk and Shared Decision Making in Primary Care [Ann Fam Med 6(3): 218, 2008]
Study 2: Patients Prefer Pictures to Numbers to Express Cardiovascular Benefit From Treatment [Ann Fam Med 6(3): 213, 2008]
Sept
2
Emergency Medicine: Etomidate for Rapid-Sequence Intubation: Friend or Foe? - J. McCabe

Editorial: Should etomidate be used for rapid-sequence intubation induction in critically ill septic patients? [ Am J Emerg Med 26: 229, 2008]
Commentary: Clinical Controversies: Etomidate as an Induction Agent for Endotracheal Intubation in Patients With Sepsis [Ann Emerg Med 52(1): 13, 2008]
Study: Randomized Clinical Trial of Etomidate Versus Propofol for Procedural Sedation in the Emergency Department [Ann Emerg Med. 49: 15, 2007]
9
Medical Genetics: Mutations in Acute Myeloid Leukemia - R. Lebel

Editorial: Diagnosis and Prognosis in Acute Myeloid Leukemia - The Art of Distinction [NEJM 358(18): 1960, 2008]
Study:
Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia [NEJM 358(18): 1909, 2008]
16
Pediatrics/Nephrology: Controversy Regarding The Usage of Acyclovir Therapy in Neonates - T. Welch

Study: The Prevalence of Neonatal Herpes Simplex Virus Infection Compared with Serious Bacterial Illness in Hospitalized Neonates [ J Pediatr 153: 164, 2008]
Editorial #1: When Should You Initiate Acyclovir Therapy in a Neonate? [ J Pediatr 153: 155, 2008]
Editorial #2: In Defense of Empiric Acyclovir Therapy in Certain Neonates [J Pediatr 153: 157, 2008]
23
Psychiatry: Vagus Nerve Stimulation in the Treatment of Depression - T. Schwartz

Editorial: Approving the Vagus-Nerve Stimulator for Depression [NEJM 356(16): 1604]
Study 1: Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial [Biol Psychiatry 58: 347]
Study 2: A One-Year Comparison of Vagus Nerve Stimulation with Treatment as Usual for Treatment-Resistant Depression [Biol Psychiatry 58: 364]
Oct
7
Public Health - C. Morrow
14
Pathology (session will originate from Binghamton Clinical Campus) – J. Terzian
21
Radiation Oncology – J. Bogart
28
OB/GYN - L. Dutton
Nov
4
Surgery/Trauma - J. Fortune
11
Psychiatry – M. Dewan
18
ENT – R. Kellman
Dec
2
Neurology – J. Shefner
9
Gastroenterology – R. Szyjkowski
16
Nephrology - S. Scheinman
     
Jan
6
Urology - F. Daneshgari
13
Clinical Pharmacology: Role of Pharmacogenomic Testing for Personalizing Medicine - D. Lehmann
20
Endocrinology: Osteoporosis - A. Moses
27
Pediatrics (session will originate from Binghamton Clinical Campus) – L. Lesperance
Feb
3
Ophthalmology – R. Barlow
10
Regenerative Medicine – T. Poole
17
Dermatology - R. Farah
24
Microbiology/Global Health - Burkitt’s Lymphoma/EBV Link – R. Rochford
Mar
3
Orthopedic Surgery - D. Katz
10
TBA


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