MSII Schedule

MLC II : Pathophysiologic Mechanisms of Disease (Spring 2012)

Class meets on Mondays & Fridays from 11:00-12:30 p.m. and Wednesdays from 11:00-11:50 a.m. in 1159 Weiskotten unless otherwise indicated.

Quiz Schedule:

Level I: The first quiz on a given case
"Closed book" quiz assessing general understanding of the facts of the case; no typed or handwritten material allowed

Level II: Follow-up quizzes on a given case
Quizzes will be “open paper, open notes” assessing deeper, mechanistic understanding of the events of the case; both the published paper and any handwritten notes are allowed along with your pathophysiologic hypothesis; no other typed/Xeroxed material is permitted
* Format Will Generally Proceed as Follows Unless Otherwise Specified

Hypothesis Schedule:

Case wrap-up session on Friday

Hypothesis due by 8 a.m. in Blackboard

Unit VI

Week 1	Feb	15	Read: Case 32-2010 (* note 10:00 a.m start time)
		17	Assignment: FDA approval of Bevacizumab for Breast Cancer Read: The Avastin Story Read: Changing End Points in Breast-Cancer Drug Approval - The Avastin Story Read: Reputation and Precedent in the Bevacizumab Decision

Week 2	Feb	20	Read: Case 31-2006
		22
		24	Hypothesis due; case wrap-up

Week 3	Feb	27	Read: Case 13-2010
		29
	Mar	2	Hypothesis due; case wrap-up

Week 4	Mar	5	Read: Case 39-2010
		7
		9	Hypothesis due; case wrap-up

Week 5	Mar	12
		14
		16	Unit VI Examination

Normal lab values at MGH [NEJM 351(15):1548, 2004]

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