Major Research Areas
Researchers in the College of Graduate Studies focus their efforts where it truly matters—on the diseases and illnesses that affect many people. Much of our research activity is grouped into four areas of concentration: cancer; infectious diseases; disorders of the nervous system; and diabetes, metabolic disorders and cardiovascular diseases.
Megan E Oest, PhD
Research Programs and Affiliations
- Biomedical Sciences Program
- Cancer Research Institute
- Orthopedic Surgery
Education & Fellowships
- Postdoctoral Fellow: Virginia Tech, 2008
- PhD: Georgia Institute of Technology, 2007, Bioengineering
- BS: Oregon State University, 2001, Bioengineering
Radiation damage to bone; mechanical regulation of bone cell behavior; mesenchymal stem cells; orthopedic tissue engineering; fetal basis of adult disease.
HealthLinkOnAir Radio Interview9/18/14 Radiotherapy-associated bone damage
Oest ME, Franken V, Kuchera T, Strauss J, Damron TA. (2015) Long-term loss of osteoclasts and unopposed cortical mineral apposition following limited field irradiation. Journal of Orthopaedic Research epub 18 Nov 2014.
Oest ME, Damron TA. (2014) Focal therapeutic irradiation induces an early transient increase in bone glycation. Radiation Research 181(4):439-43.
Oest ME, Miller MA, Howard KI, Mann KA. (2014) A novel in vitro loading system to produce supraphysiologic fluid shear stress. Journal of Biomechanics 47(2):518-525.
Gong B, Oest ME, Mann KA, Damron TA, Morris MD. (2013) Raman Spectroscopy Demonstrates Prolonged Alteration of Bone Chemical Composition Following Extremity Localized Irradiation. Bone 57(1):252-258.
Keenawinna L, Oest ME, Mann KA, Spadaro JA, Damron TA. (2013) Zoledronic Acid Prevents Loss of Trabecular Bone Following Focal Irradiation in Mice. Journal of Radiation Research 180(1):89-99.
Wojtowitcz AM, Shekaran A, Oest ME, Dupont KM, Templeman KL, Hutmacher DW, Guldberg RE, Garcia AJ. (2010) Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair. Biomaterials, 31(9): 2574-2582.
Liang C, Oest ME, Jones JC, Prater MR. (2009) Gestational high saturated fat diet alters C57BL/6 mouse perinatal skeletal formation. Birth Defects Research Part B Developmental and Reproductive Toxicology, 86(5):377-384.
Liang C, Oest ME, Prater MR. (2009) Intrauterine exposure to high saturated fat diet elevates risk of adult-onset chronic diseases in C57Bl/6 mice. Birth Defects Research Part B Developmental and Reproductive Toxicology, 86(5):362-369.
Oest ME, Jones JC, Hatfield C, Prater MR. (2008) Micro-CT evaluation of murine fetal skeletal development yields greater morphometric precision over traditional clear-staining methods. Birth Defects Research Part B Developmental and Reproductive Toxicology 83(6):582-589.
Guldberg RE, Duvall CL, Peister A, Oest ME, Lin AS, Palmer AW, Levenston ME. (2008) 3D imaging of tissue integration with porous biomaterials. Biomaterials 29 (28):3757-3761.
Guldberg RE, Oest ME, Dupont K, Peister A, Deutsch E, Kolambkar Y, Mooney D. (2007) Biologic augmentation of polymer scaffolds for bone repair. Journal of Musculoskeletal and Neuronal Interactions 7(4):333-334.
Duty AO, Oest ME, Guldberg RE. (2007) Cyclic mechanical compression in vivo increases mineralization of cell-seeded polymeric orthopaedic tissue constructs. Journal of Biomechanical Engineering 129(4):531-539.
Oest ME, Dupont KM, Kong, HJ, Mooney, DJ, Guldberg RE. (2007) Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects. Journal of Orthopaedic Research 25(7):941-950.
Rai B, Oest ME, Dupont KM, Ho KH, Teoh SH, Guldberg RE. (2007) Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair. Journal of Biomedical Materials Research A 81(4):888-899.
Guldberg RE, Oest ME, Lin AS, Ito H, Chao X, Gromov K, Goater JJ, Koefoed M, Schwarz EM, O'Keefe RJ, Zhang X. (2004) Functional integration of tissue-engineered bone constructs. Journal of Musculoskeletal and Neuronal Interactions 4(4):399-400.
Guldberg RE, Ballock RT, Boyan BD, Duvall CL, Lin AS, Nagaraja S, Oest ME, Phillips J, Porter BD, Robertson G, Taylor WR. (2003) Analyzing bone, blood vessels, and biomaterials with microcomputed tomography. IEEE Engineering in Medicine and Biology 22(5):77-83.
Bower CK, Parker JE, Higgins AZ, Oest ME, Wilson JT, Valentine BA, Bothwell MK, McGuire J. (2002) Protein antimicrobial barriers to bacterial adhesion: in vitro and in vivo evaluation of nisin-treated implantable materials. Colloids and Surfaces B: Biointerfaces 25(1):81-90.