Major Research Areas
Researchers in the College of Graduate Studies focus their efforts where it truly matters—on the diseases and illnesses that affect many people. Much of our research activity is grouped into four areas of concentration: cancer; infectious diseases; disorders of the nervous system; and diabetes, metabolic disorders and cardiovascular diseases.
Russell T Matthews, PhD
- Associate Professor of Neuroscience and Physiology
Research Programs and Affiliations
- Biomedical Sciences Program
- Neuroscience Program
- Neuroscience and Physiology
- Physiology Program
Education & Fellowships
- PhD: Yale University, 2001, Neurobiology
- Role of glycoproteins in oncogenesis and brain development
Understanding the roles of Extracellular Matrix Molecules and Cell-Surface Glycoproteins in Brain Development and DiseaseThe extracellular environment in the central nervous system plays critical roles in all stages of development and in learning and memory in the adult nervous system. Alteration or disruption of this neural extracellular environment can have devastating functional consequences and is implicated in a vast array of neural pathologies and in neural injury. Research in the Matthews laboratory is focused on identifying the cell-surface glycoconjugates and extracellular matrix molecules that comprise the neural extracellular space and understanding their roles in the developing nervous system and in neural pathologies and neural trauma. Work from my lab has uncovered the roles of a family of glycoproteins in the establishment and maintenance of the precise connectivity in the central nervous system and we continue to work towards understanding the functional roles of these molecules in learning and memory. Our work has demonstrated the heterogeneous nature of the molecules in the brain and the disruption of these structures with sensory deprivation. In addition, our work has demonstrated that some of the same molecules that are important for central nervous system development, are also disrupted and modified in neuropathologies such as glioma and play an important role in the progression of these diseases. The overarching goal of the work in my laboratory is to identify the molecular substrates of development and disease in the mammalian CNS.
Selected Publications:1. Matthews, R. T., G. M. Kelly, C. Zerillo, G. Gray, M. Tiemeyer and S. Hockfield. 2002. Aggrecan gycoforms contribute to the heterogeneity of perineuronal nets. Journal of Neuroscience. 2002. 22: 7536-7547.
2. Matthews, R.T., C. Lander and S. Hockfield. The Extracellular matrix of the peripheral and central nervous system. In: The Encyclopedia of Neuroscience, 3rd Edition. Adelman, G. and Smith, B. H. Amsterdam: Elsevier Science. 2004.
3. Viapiano M. S., Matthews R. T., From barriers to bridges: chondroitin sulfate proteoglycans in neuropathology. Trends Mol Med. 2006 Oct;12(10):488-496.
4. Dino M. R., Harroch S., Hockfield S., Matthews R. T. Monoclonal antibody Cat-315 detects a glycoform of receptor protein tyrosine phosphatase beta/phosphacan early in CNS development that localizes to extrasynaptic sites prior to synapse formation. Neuroscience. 2006. 142(4):1055-69.