Shengle Zhang, MD

Shengle Zhang, MD
Appointed 07/01/04
6804C Upstate University Hospital - Downtown Campus
750 East Adams Street
Syracuse, NY 13210

315 464-4750

Current Appointments

  • Associate Professor of Pathology
  • Medical Director of Molecular Diagnostics for Anatomic Pathology

Hospital Campus

  • Downtown

Clinical Section Affiliations

  • Pathology: Anatomic Pathology, Lymphocyte Lab, Molecular Diagnostics for Anatomic Pathology, Surgical Pathology

Research Programs and Affiliations

  • Cancer Research Institute
  • Pathology

Web Resources

Education & Fellowships

  • Fellowship: Johns Hopkins Medical Institutions, Maryland., 2004, Molecular Genetic Pathology/Molecular Diagnostics
  • Fellowship: Roswell Park Cancer Center, New York, 2002, Oncologic Pathology
  • Residency: Saint Barnabas Health Care System, New Jersey, 2001, Anatomic and Clinical Pathology
  • MS: Shangdong Academy of Medical Sciences, 1985, Biochemistry
  • MD: Wannan Medical College, China, 1982, Medicine

Clinical Interests

  • Surgical pathology, molecular pathology

Research Interests

  • Molecular Oncology and its clinical application.

Specialties & Certification

  • Anatomic and Clinical Pathology
  • Molecular Diagnostics (ABCC)
  • Molecular Genetic Pathology


  • Adults and Children


  • Genetic Testing
  • Laboratory Services


  • American Society for Clinical Pathology
  • Association of Molecular Pathology (AMP)
  • United States and Canadian Academy of Pathology
  • American Association for Cancer Research (AACR)

Current Hospital Privileges

  • Upstate University Hospital

Web Resources


Link to PubMed External Icon (Opens new window. Close the PubMed window to return to this page.)

Research Abstract

Recent Selected References:

1. Narendra, S, Valente, A, Tull J, BS, Zhang, S.  DDIT3 Gene Break-Apart as a Molecular Marker for

    Diagnosis of Myxoid Liposarcoma - Assay Validation and Clinical Experience. Diagn Mol Pathol, 

    20:218-224, 2011.

2. Swati, I, Zhang S, Tull, J, Khurana KK. Accuracy of cytology specimen and needle core biopsies

    for detection of KRAS mutation in non-small cell carcinoma: comparison with resection specimen. World J Oncol. 2(6):275-280, 2011.

3. Zhang S, Pavlovitz B, Tull J, Wang Y, Deng F, Fuller C. Detection of TMPRSS2 gene deletions and

    translocations in carcinoma, intraepithelial neoplasia and normal epithelium of the prostate by

   direct fluorescence in situ hybridization. Diagn Mol Pathol, 19:151-156, 2010.

4. Rong R, Doxtader EE, Tull J, Zhang S. Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary - molecular genetic analysis.  Int J Clin Exp Pathol, 3(2):217-221, 2010.

5. El-Zammar O, Zhang S, Katzenstein ALA. Comparison of FISH, PCR, and Immunohistochemistry in assessing EGFR status in lung adenocarcinoma and correlation with clinicopathologic features. Diagn Mol Pathol, 18:133-137, 2009.

6. Shah SS, Wang Y, Tull J and Zhang S. Effect of high copy number of HER2 associated with polysomy 17 on HER2 protein expression in invasive breast carcinoma. Diagn Mol Pathol, 18:30-33, 2009.

7. Mehra S, de la Roza G, Tull J, Shrimpton A, Valente A, Zhang S.  Detection of FOXO1(FKHR) gene break-apart by fluorescence in situ hybridization (FISH) in formalin fixed paraffin embedded alveolar rhabdomyosarcomas and its clinicopathological correlation. Diagn Mol Pathol, 17:14-20, 2008.

8. Nasr, MR, Mukhopadhyay S, Zhang S and Katzenstein A-L: Immunohistochemical markers in diagnosis of papillary thyroid carcinoma: utility of HBME1 combined with CK19 immunostaining. Mod Pathol, 19:1631-1637, 2006.

9. Murphy K, Zhang S, Geiger T, Hafez MJ, Bacher J, Berg KD and Eshleman J. Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers.  J Mol Diagn  8:305-11, 2006.

10. Montgomery E, Mamelak AJ, Gibson M, Maitra A, Sheikh S, Amr SS, Yang S, Brock M, Forastiere A, Zhang S, Murphy K, Berg K.  Overexpression of Claudin Proteins in Esophageal Adenocarcinoma and its Precursor Lesion.  Appl Immunohisto Mol Morph. 14:24-30, 2006.

11.Zhang S, Ashraf M and Schinella R: Ischemic colitis with atypical reactive changes mimicking dysplasia (pseudodysplasia). Archives of Pathology and Laboratory Medicine, Arch Path Lab Med, 125:224-227, 2001.

12.Zhang S and Schinella R: Expression of ER, PR, Her2/neu and Ki-67 and their correlation in 55 cases of infiltrating ductal carcinoma of the breast. Journal of Tumor Marker Oncology, 15:123-127, 2000.

13. Zhang S,  Zhang HS, Cordon-Cardo C, Ragupathi G, Livingston PO: Selection of tumor antigens as targets for immune attack using immunohistochemistry : protein antigens. Clin Cancer Res  4:2669-76, 1998.

14. Zhang S, Zhang HS, Reuter VE, Slovin SF, Scher HI, Livingston PO: Expression of potential target antigens for immunotherapy on primary and metastatic prostate cancers. Clin Cancer Res  4:295-302, 1998.

15. Zhang S, Zhang HS, Cordon-Cardo C, Reuter VE, Singhal AK, Lloyd KO, Livingston PO:

     Selection of carbohydrate tumor antigens as targets for immune attack using

     immunohistochemistry. II.blood group-related antigens. Int J Cancer, 73:42-9, 1997.

16. Zhang S, Cordon-Cardo C, Zhang HS, Reuter VE, Adluri S, Hamilton B, Lloyd KO, Livingston PO: Selection of carbohydrate tumor antigens as targets for immune attack using immunohistochemistry I. focus on gangliosides. Int J Cancer, 73:50-56, 1997.

17. Zhang S, Walberg LA, Helling F, Ragupathi G, Adluri S, Lloyd K O, Livingston PO: Augmenting the immunogenicity of synthetic MUC1 peptide vaccines in mice. Cancer Res, 56:3315-19, 1996.

18. Zhang S, Walberg LA, Ogata S, Itzkowitz S H, Koganty RR, Reddish M, Longenecker BM, Lloyd KO, Livingston PO: Immune sera and monoclonal antibodies define two configurations for the sialyl Tn tumor antigen. Cancer Res 55:3364-68, 1995.

19. Zhang S, Helling F, Lloyd KO, Livingston PO: Increased tumor cell reactivity and complement dependent cytotoxicity with mixtures of monoclonal antibodies against different gangliosides. Cancer Immunol Immunother 40:88-94, 1995.



Clinical Profile Shortcut:
Faculty Profile Shortcut:
Sue Stearns in anatomy lab

Sue Stearns, PhD, is an associate professor of cell and developmental biology, and one of four faculty members who teach Gross Anatomy to first-year medical students at SUNY Upstate. Students routinely cite this course as a favorite.

Read more about Stearns' take on our Anatomy course's popularity.