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Infectious Disease Research

SUNY Upstate Medical University Public Health and Preventive Medicine Grand Rounds 10/22/2015

Climate Drivers of Emerging Infectious Diseases: Research Advances in Ecuador presented by Anna Stewart Ibarra, PhD MPA 

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Active Projects

Title: Exploration of immunologic mechanisms of immune interference and/or cross-neutralizing immunity following administration schedules with CYD tetravalent dengue vaccine.

2012-2016

PI: Mark Polhemus

Purpose: The major goals of this project are a Phase II trial of a dengue vaccine.

This project is supported by the Department of Defense.


Title: Immunogenicity of a two vs. three dose, Intradermal (ID) vs. Intramuscular (IM) administration of a licensed rabies vaccine for pre-exposure vaccination.

PI: Mark Polhemus

2012-2015

Purpose: The major goals of this project are evaluation of different dosing regimens of a licensed rabies vaccine for use in pre-exposure prevention of disease.

This project is supported by the Department of Defense-Military Vaccine Agency.


Title: The Effect of Antimalarial Drugs on the Immune Response to Rabies Vaccine for Post-Exposure Prophylaxis.

PI: Mark Polhemus

2012-2015

Purpose: The major goals of this project are evaluation of the effect of antimalarial drugs on the immune response and development of protective antibodies with standard rabies vaccination.

This project is supported by the Department of Defense-Military Vaccine Agency.


Title: Capacity strengthening in Ecuador Year 2: Partnering to improve surveillance of febrile vector-borne diseases.

PI and Co-PIs: Mark Polhemus, Timothy Endy, Anna Stewart Ibarra

2012-2015

Purpose: The major goals of this study are strengthening of the surveillance efforts in Ecuador and development of a research platform to evaluate climate, vector, and disease impact on the country.

This project is supported by the Department of Defense-Global Emerging Infections Surveillance.


Title: Dengue virus circulation, evolution, virus-vector, and virus-host interactions in Kamphaeng Phet Province, Thailand.

PI: Timothy Endy

2011-2015

Purpose: The major goal of this study is to use geographic information system analysis of the microevolution of dengue viruses.

This project is supported by the Department of Defense-Telemedicine and Advanced Technology Research Center.


Title: Using advanced proteomics to understand vaccine induced immunogenicity.

PI: Timothy Endy

2012-2015

Purpose: The major goals of this project are utilizing proteomics to identify unique biomarkers after dengue vaccination for induced protective immunogenicity.

This project is supported by the Department of Defense-Military Infectious Diseases Research Program.


Title/Purpose: Ecuador-U.S. collaboration to investigate interactions among infectious diseases and nutrition

PI: Anna Stewart

2014-2016

This project is supported by the National Secretary of Higher Education, Science, Technology and Innovation of Ecuador.<


Title/Purpose: Developing an operational research framework to assess local flood response capacities: A case study of rural coastal community in Ecuador

PI: Anna Stewart

2014-2015

This project is supported by the Intramerican Institute for Global Change Research.


Title/Purpose: Interactions among climate variability and the occurrence of Harmful Algal Blooms (HABs) and their impact on human health in an estuarine-coastal gradient (Guayaquil-Santa Elena)

2015-2017

PI: Anna Stewart

This project is supported by Escuela Superior Politcenia del Litoral.

Past Projects

Title: Evaluating the potential use of oceanographic information and remotely sensed algal blooms to predict risk of Cholera and other water sensitive diseases.

PI: Mark Polhemus, Timothy Endy, Anna Stewart Ibarra

2013-2014

Purpose: The major goals of this study are evaluating a novel strategy for cholera surveillance in environmental waters, and public health capacity building in Ecuador, including development of an intensive geospatial research methods course.

This project is supported by the Department of Defense-Global Emerging Infections Surveillance.


Title: Impact of subcutaneous versus intramuscular administration of Inviragen’s live attenuated dengue vaccine on safety and immunogenicity.

PI: Mark Polhemus

2012-2014

Purpose: The major goals of this project are a Phase II trial of a dengue vaccine.

This project is supported by the Department of Defense-Military Vaccine Agency.


Title: Dengue virus diversity in Northern Thailand.

PI: Timothy Endy

2008-2014

Purpose: The major goal of this project is a long-term study to determine dengue genetic diversity and the ecologic effects of a live-attenuated tetravalent dengue vaccine.

This project is supported by the National Institute of Allergy and Infectious Disease.


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