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original: wild-type paxillin cells
rollover: paxillin lacking LD4 cells

These cells were scratch-wounded followed by fixation 12-hours post-wounding. Tubulin (Green) and alpha-mannosidase II (Red) were labeled to note cell polarization and Golgi orientation. Cells expressing paxillin lacking LD4 are unable to reorient the Golgi towards the wound edge. From the lab of Christopher Turner, PhD.

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Below are images from the current topics under investigation in the Department of Cell and Developmental Biology. For further information on these and related projects, visit the faculty and labs pages.

From the research of David Mitchell, Ph.D. Immunofluorescent image of a single Chlamydomonas cell stained for flagellar dynein protein IC2 (green) and intraflagellar transport protein IFT46 (red). The IFT protein, required for dynein assembly, is concentrated at basal bodies and in patches along each flagellum, whereas assembled dynein is evenly distributed on the flagella and unassembled dynein is seen in puncta in the cytoplasm.From the research of Christopher E. Turner, Ph.D. Triple-labeled immunofluorescence image of Normal Rat Kidney cells. Red staining corresponds to the focal adhesion protein paxillin. The actin cytoskeleton is labeled in green and the nuclei are stained blue. Paxillin is a multi-domain adapter protein that provides an important link between the actin cytoskeleton and transmembrane integrin receptors.From the research of Jean Sanger, Ph.D. Confocal image of a projection of focal planes through a three day-old embryonic zebrafish heart (ventricle V and atrium A) showing the distribution of the forming myofibrils. Nuclei, stained with DAPI are blue. Actin and myosin were stained with fluorescent phalloidin (red) and myosin antibodies (green).From the research of James S. McCasland, Ph.D. Flattened left hemisphere of GAP-43 wildtype (+/+) mouse cortex immunostained with serotonin transporter (5HT-T). The layer IV thalamocortical afferents show a complete body map: V: visual, A: auditory, a-e: large whiskers, SW: small whiskers, LL: lower lip, FL: forelimb, T: trunk, HL: hindlimb. Reference: PNAS Vol. 96, pp. 9397-9402, August 1999.From the research of David W. Pruyne, Ph.D. Shown is the head of a Caenorhabditis elegans adult worm expressing the formin, FHOD-1, fused to GFP. The fusion protein shows the formin is expressed in the large pharynx within the head, and in the body wall muscles in the form of small puncta near the surface of the worm's body.From the research of Thomas J. Poole, Ph.D. The dorsal hindlimbs of day 3 (left) and day 3.75 (right)  Japanese quail embryos labeled to show neurites (green) and endothelial cells (red) and viewed by fluorescent confocal microscopy.