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original: wild-type paxillin cells
rollover: paxillin lacking LD4 cells

These cells were scratch-wounded followed by fixation 12-hours post-wounding. Tubulin (Green) and alpha-mannosidase II (Red) were labeled to note cell polarization and Golgi orientation. Cells expressing paxillin lacking LD4 are unable to reorient the Golgi towards the wound edge. From the lab of Christopher Turner, PhD.

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CDB Research

Cell and Developmental Biology Research

Research in the Department of Cell and Developmental Biology explores the molecular and biochemical mechanisms of cellular function and development. Research in the Department of Cell and Developmental Biology is in several exciting areas:

  • Assembly and Dynamics of Myofibrils
  • Genetics and cell biology of organ morphogenesis
  • Genetics of ciliary motility
  • Mammalian neural development and regeneration
  • Mechanisms of actin assembly during endocytosis
  • Role of class I myosins in kidney functions
  • Role of cell adhesion in regulating the cytoskeleton and cell motility
  • Role of Formins in animals

Other projects include: studies of embryonic blood vessel development and of signaling cascades that control cellular proliferation and differentiation.