• Triple-labeled immunofluorescence image of Rat Kidney cells.
    Triple-labeled immunofluorescence image of Rat Kidney cells.
  • A three day-old embryonic zebrafish heart.
    A three day-old embryonic zebrafish heart.
  • Immunofluorescent image of a single Chlamydomonas cell.
    Immunofluorescent image of a single Chlamydomonas cell.
  • Flattened left hemisphere of GAP-43 wildtype mouse cortex.
    Flattened left hemisphere of GAP-43 wildtype mouse cortex.
  • The head of a Caenorhabditis elegans adult worm.
    The head of a Caenorhabditis elegans adult worm.
  • The dorsal hindlimbs of Japanese quail embryos.
    The dorsal hindlimbs of Japanese quail embryos.

Cell and Developmental Biology Research

RESEARCH PROFILE
original: wild-type paxillin cells
rollover: paxillin lacking LD4 cells

These cells were scratch-wounded followed by fixation 12-hours post-wounding. Tubulin (Green) and alpha-mannosidase II (Red) were labeled to note cell polarization and Golgi orientation. Cells expressing paxillin lacking LD4 are unable to reorient the Golgi towards the wound edge. From the lab of Christopher Turner, PhD.

Check out our Research Gallery

Research in the Department of Cell and Developmental Biology explores the molecular and biochemical mechanisms of cellular function and development. Research in the Department of Cell and Developmental Biology is in several exciting areas:

  • Assembly and Dynamics of Myofibrils
  • Genetics and cell biology of organ morphogenesis
  • Genetics of ciliary motility
  • Mammalian neural development and regeneration
  • Mechanisms of actin assembly during endocytosis
  • Role of class I myosins in kidney functions
  • Role of cell adhesion in regulating the cytoskeleton and cell motility
  • Role of Formins in animals

Other projects include: studies of embryonic blood vessel development and of signaling cascades that control cellular proliferation and differentiation.

Labs

AmackAmack Lab

Led by Jeffrey Amack, PhD. We study genes and mechanisms that control organ formation during embryo development. Amacklab.orgExternal Icon

Blystone

Blystone Lab

Led by Scott Blystone, PhD. Lab studies Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype.

Krendel

Krendel Lab

Led by Mira Krendel, PhD. Our lab studies physiological functions of myosin motors that move various cargoes along actin filaments. Learn more...

Mitchell

Mitchell Lab

Led by David Mitchell, PhD. Research interests: Regulation of ciliary dynein activity and assembly, and the role of the central pair complex in ciliary motility regulation.

Osterhout Lab

Led by Donna Osterhout, PhD. Research interests: Biology of oligodendroglia and myelin formation during development, remyelination and repair in spinal cord injury and MS

Poole

Poole Lab

Led by Thomas Poole, PhD. Research interests: Vascular development and the alignment of growing nerves and blood vessels in quail and zebrafish embryos.

Pruyne

Pruyne Lab

Led by David Pruyne, PhD. Research interests: Biochemistry and cell biology of formins as actin cytoskeleton organizers, using Caenorhabditis elegans as a model system.

Joseph Sanger, PhD

Jean Sanger, PhD

Sanger Lab

Led by Jean Sanger, PhD and Joseph Sanger, PhD. The complex regulation of eukaryotic proteins in response to cellular events such as division, development and bacterial infection involves dramatic reorganization of the cytoskeleton. Understanding the mechanisms and the numerous proteins involved in these architectectural rearranglements is the primary focus of our research. Learn more...

Sirotkin

Sirotkin Lab

Led by Vladimir Sirotkin, PhD. Research interests: Mechanisms of the actin cytoskeleton assembly and role of myosin-1 during endocytosis in fission yeast.

Turner

Turner Lab

Led by Christopher Turner, PhD. Research interests: We are interested in understanding the molecular mechanisms and signaling pathways that regulate cell adhesion and cell migration associated with cancer cell metastasis, development and wound repair. Learn more...

Top