Robert W Zajdel, PhD

Robert W Zajdel, PhD
Appointed 08/29/91
143 Weiskotten Hall
766 Irving Ave.
Syracuse, NY 13210

315 464-8530

Current Appointments

Hospital Campus

  • Downtown

Education & Fellowships

  • PhD: SUNY Health Science Center at Syracuse, 1997

Clinical Interests

  • Clinical anatomy.

Education Interests

  • Teaching in the medical college and health professions.  Current classes and experience include Medical Gross anatomy, Microscopic anatomy, Neuroanatomy, Physical Therapy anatomy, Medical Cellular Physiology- small group, Biochemistry and Cell Biology-Post baccalaureate program.

    Advisory Dean for MS1-4.  MSPE letter writer.

Research Interests

  • Not currently doing wet lab research. Expression of myofibrillar proteins at the early stages of heart development.

Research Abstract

Striated muscle tropomyosin is classically described as consisting of 10 exons, 1a, 2b, 3, 4, 5, 6b, 7, 8, and 9a/b, in both skeletal and cardiac muscle. Experiments in our laboratory have demonstrated expression of a naturally occurring chimeric isoform of tropomyosin that has both smooth and striated muscle exons. The chimeric isoform has a replacement of exon 2a for 2b that is commonly found in striated isoforms. GFP constructs were used to demonstrate translation and incorporation into organized myofibrils. Antisense oligonucleotide transfection decreased the expression of this isoform and disrupted organization and function.

Selected References

Wang J., H. Thurston,  E. Essandoh, M. Otto, M. Han, A. Rajan, S. Dube, R. W. Zajdel, J. M. Sanger,  K.K. Linask, D.K. Dube, J.W. Sanger. (2008) Tropomyosin expression and dynamics in developing avian embryonic muscles.  Cell Motil. Cytoskel. 65:379-392.

Zajdel, R. W., H. Thurston, S. Prayaga, S. Dube, B.J. Poiesz,  D. K. Dube.  (2007). A reduction of tropomyosin limits development of sarcomeric structures in cardiac mutant hearts of the Mexican axolotl. Cardiovasc Toxicol.  7:235-246.

Zajdel, R. W., M. D. McLean, Denz, C.R., Dube S., Thurston H. L., Poiesz, B. J., D. K. Dube.  (2006).  Differential expression of tropomyosin during segmental heart development in Mexican axolotl.  J. Cell Biochem. 99: 952-965.

Zajdel, R. W., C. R. Denz, A. Narshi, Syamalima Dube, D. K. Dube. (2005).  Anti-sense mediated inhibition of expression of the novel striated tropomyosin isoform TPM1κ disrupts myofibril organization in embryonic axolotl hearts.   J. Cell. Biochem.   95: 840-848.

Denz, C. R., A. Narshi, R. W. Zajdel, D. K. Dube. (2004).  Expression of a novel cardiac-specific tropomyosin isoform in humans.  Biochem. Biophys. Res. Commun.  320: 1291-129.

 

 

 

 

Faculty Profile Shortcut: http://www.upstate.edu/faculty/zajdelr

Faculty Honors

Dr. Dennis Stelzner has been elected a Fellow in the American Association of Anatomists. He was presented with a citation and plaque at the annual meeting of the American Association of Anatomists during the FASEB meeting on April 12, 2011 in Washington, DC.

The citation reads:
Spinal cord injury (SCI) has been studied during his entire career using neuroanatomical and ultrastructural methods. He showed that the ability of nerve tracts to regenerate or grow around partial SCI during development is dependent on their maturation at the time of injury.

Differences were also found in the ability of frog optic and tectal efferent axons to regenerate through the same diencephalic injury. The intrinsic cellular response needed for CNS axons to regenerate is the focus of his present work on propriospinal neurons using "molecular neuroanatomy" to determine factors underlying a maximal regenerative response after spinal cord injury.