"Being responsible for my own research project has been a great incentive to step out of my scientific comfort zone and explore areas less familiar to me such as Molecular Biology. These bacteria were transformed to produce a plasmid containing a synthetic piece of double stranded DNA I designed." - Lisi Krainer
Using live-cell imaging and biochemical approaches our laboratory examines the interface between cytoskeletal dynamics, mitotic signaling, and membrane transport during cell division
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The Hehnly Laboratory focuses on the relationship between cytoskeletal dynamics, vesicle transport, and localized signaling events, employing both microscopy and biochemical approaches. The overal question of the Hehnly Lab is how the microtubule organizing center, or centrosome, regulates cell functions that include mitotic spindle assembly, cell polarity, vesicle trafficking, and primary cilia formation. Studies stemming from this identified that the centrosome, specifically a substructure of the centrosome called mother centriole appendages, directly modulates and organizes a specific components of the endocytic pathway and a mitotic-kinase, Plk1. These studies create a unique scientific niche to examine how the centrosome, and its appendage-like substructures, are required for regulating membrane trafficking and Plk1-dependent signaling.