About the Program in Cell and Developmental Biology
Research in the Department of Cell and Developmental Biology is focused in two main areas:
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wild-type paxillin cells
paxillin lacking LD4 cells
Cells expressing wild-type paxillin (top) or paxillin lacking LD4 (bottom) were scratch-wounded followed by fixation 12 hours post-wounding. Tubulin (Green) and alpha-mannosidase II (Red) were labeled to note cell polarization and Golgi orientation. Cells expressing paxillin lacking LD4 are unable to reorient the Golgi towards the wound edge. From the lab of Christopher Turner, PhD.
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- Mammalian neural development and regeneration
— includes the ability of stem cells to repair injuries in the central nervous system, the role of specific genes in development of somatosensory connections in the neonate, and development of the neuromuscular junction.
- Role of cell adhesion in regulating the cytoskeleton and cell motility — includes work on regulation of the leukocyte actin cytoskeleton by integrin activation, regulation of fibroblast adhesion to the extracellular matrix through the formation of focal adhesion complexes, and regulation of flagellar motility in response to changes in intracellular calcium ion signaling.
Other projects include: studies of embryonic blood vessel development and of signaling cascades that control cellular proliferation and differentiation.
Students and faculty use a variety of research methods including sophisticated light microscopy (automated motility tracking, laser confocal microscopy, high-resulution dark-field imaging, real-time fluorescence microscopy, high-sensitivity digital cameras and image processing), electron microscopy, tissue culture, stereotactic surgery, flow cytometry and a complete range of molecular and biochemical techniques.
This program awards a PhD degree in Anatomy and Cell Biology.
Joseph W. Sanger, PhD, Chair
Department of Cell and Developmental Biology
SUNY Upstate Medical University
1135 Weiskotten Hall
766 Irving Ave.
Syracuse, NY 13210
315-464-5120
www.upstate.edu/cdb
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