Diana M Gilligan, MD/PhD

Current Appointments

• Associate Professor of Medicine
• Associate Professor of Biochemistry and Molecular Biology

Hospital Campus

• Downtown

Clinic/Unit

• Regional Oncology Center
  Google Maps & Directions
  750 East Adams Street
  Syracuse, NY 13210
  315 464-8200
  
• University Physicians Hematology/Oncology Oswego
  Oswego Hospital Health Services Center
  Google Maps & Directions
  Suite 110, 140 W. Sixth Street
  Oswego, NY 13126
  315 342-6215
  

Education & Fellowships

• Fellowship: Duke University Medical Center, 1994, Clinical Fellow, Hematology/Oncology
• Fellowship: Duke University Medical Center, 1993, Postdoctoral Fellow
• Fellowship: University of North Carolina Hospitals - Chapel Hill, 1989, Postdoctoral Fellow
• Residency: North Carolina Memorial Hospital, 1989, Internal Medicine
• MD/PhD: Albert Einstein College of Medicine, 1985, Anatomy and Structural Biology
• BA: Radcliffe College, Harvard University, 1976, Biology

Specialties & Certification

• Internal Medicine
• Hematology

Diseases & Conditions Treated

• Adult Leukemia
• Adult Lymphoma
• Anemia
• Bleeding Disorders
• Blood Clots
• Chronic Lymphocytic Leukemia
• Hodgkin's Lymphoma
• Multiple Myeloma

Treats

• Adults

Treatments/Services

• Apheresis
• Blood Transfusion
• Bone Marrow Aspiration
• Bone Marrow Biopsy
• Bone Marrow Transplantation (BMT)
• Chemotherapy
• Infusional Therapies
• Lumbar Puncture
• Paracentesis
• Stem Cell Collection Procedures
• Stem Cell Transplantation
• Thoracentesis

Associations/Memberships

• American College of Physicians (ACP), Fellow
• American Society of Hematology (ASH)
• American Society for Cell Biology (ASCB)

Current Hospital Privileges

• Upstate University Hospital
• Crouse Hospital

Publications

Link to PubMed (Opens new window. Close the PubMed window to return to this page.)

Research Abstract

My research includes studies of the red blood cell membrane skeleton in patients with inherited hemolytic anemia.  We are using techniques of comparative proteomics to identify new defects in red blood cell proteins that lead to spherocytosis.  We also use mouse models with targeted deletion of red blood cell proteins in order to understand the molecular basis for membrane fragility.  We have focused on the family of adducin proteins and we have demonstrated with knockout mice that adducin has a role in red blood cell stability, learning and memory formation, and hydrocephaly.  By comparative proteomics, we having recently demonstrated that red blood cells from beta-adducin deficient mice are also deficient in NHE1, the sodium-hydrogen exchanger.  This represents a breakthrough in understanding the molecular basis for the widespread functions of adducin.  Current studies are addressing the interaction between adducin and NHE1, in order to determine how knockout of adducin can lead to loss of NHE1 in red blood cells.