Electron Microscopy reconstruction of the yeast vacuolar ATPase. Ribbon models for individual protein subunits have been fit to the electron density.
From the lab of Stephan Wilkens, PhD.
Dimitra Bourboulia, PhD
Research Programs and Affiliations
- Biomedical Sciences Program
Education & Fellowships
- Fellowship: National Cancer Institute, NIH, Bethesda, MD, 2013
- Fellowship: University of London, UK, 2007
- PhD: University of London, UK, 2004
- National Institutes of Health, 2007–2013
- University of London, UK, 1999–2007
- Extracellular signaling
- Regulatory modifications in TIMPs and MMPs
- Biological significance of extracellular protein phosphorylation in urological cancers
- American Association for Cancer Research (AACR)
- American Urological Association (AUA)
Languages Spoken (Other Than English)
Link to PubMed (Opens new window. Close the PubMed window to return to this page.)
Tumor cell growth and migration begin with the secretion of proteolytic enzymes that degrade the extracellular matrix (ECM) followed by an invasion of the tumor vasculature leading to initiation of metastasis. Matrix Metalloproteases (MMPs) and their endogenous inhibitors (TIMPs) are key components of extracellular proteolysis and regulators of the tumor microenvironment (TME). Identification of ways to inhibit early matrix proteolysis would enhance our ability to target early tumor development and prevent metastatic potential. Studies have suggested that MMP/TIMP balance is shifted towards MMP activation during cancer progression.
Our laboratory investigates molecular mechanisms of MMPs and TIMPs regulation in the extracellular space that impact homeostasis and cancer progression. Current research includes: (1) Post-translational regulation of TIMP-2 with focus on tyrosine phosphorylation, (2) Identification of novel TIMP-2 extracellular protein interactions involved in tumor cell migration and invasion, (3) Targeting extracellular signaling for the development of novel cancer therapeutics.
SUNY Distinguished Professor Emeritus
- Richard Cross, PhD
- David Turner, PhD