Patricia M. Kane, PhD

Patricia Kane, PhD
Chair & Professor

The central goals of scientists in the Biochemistry and Molecular Biology department are to research fundamental mechanisms in cells and organisms at the molecular level and to train the next generation of scientists. Our research improves human health by providing new knowledge about the molecular basis of health and disease and suggesting new therapies. Read more...

Contact: Patricia M. Kane, PhD, Professor and Chair
Location: 4265 Weiskotten Hall, 766 Irving Avenue, Syracuse, NY 13210
Phone: 315 464-5127
  • stephen
    Using disease-associated mutations to understand the biochemical regulation of a multi-subunit histone methyltransferase complex - June 2014
    Eukaryotic DNA is compacted into chromatin, which must be continually remodeled to allow for DNA processes such as transcription. The basic repeating unit of chromatin, the nucleosome, is composed of an octomer of histone proteins around which 147 base pairs of DNA is wrapped. One way chromatin remodeling is achieved is by posttransitional modification of histones. Read more...
  • dimitra
    Attack of the Killer Severer - in the Amberg Lab - May 2013
    Graduate student Dimitra Aggeli, working in the Amberg lab, has discovered how to turn the small actin binding protein into an actin filament destroying machine. Building off the previous work by graduate student Mike Clark, Dimitra has been trying to understand why some of Mike's mutants are hyperactive for actin filament disassembly. Read more...
  • shahpic
    Understanding ε-mediated inhibition of bacterial F-type ATP synthase to develop drugs against Mycobacterium tuberculosis in the Duncan Lab - March 2013
    Mycobacterium tuberculosis (MTB) is an infectious pathogen that causes Pulmonary Tuberculosis and kills over one million people every year. It is also a major cause of death in HIV patients. Evolution of extreme drug-resistant strains in MTB poses a serious problem towards its treatment. As a result, there is an ongoing need to develop novel drugs that can effectively fight the resistant strains. Read more...
  • rebecca_oot
    New Insight into the Reversible Dissociation of the V-ATPase Revealed by the Wilkens Lab - April 2012
    The vacuolar ATPase (V-ATPase) is a rotary molecular motor enzyme that functions to acidify the lumen of subcellular organelles in all eukaryotic cells. V-ATPase function is involved in a number of fundamental cellular processes including pH/ion homeostatis, endocytosis, vesicular traffic and antigen processing. Read more...
  • cosgrove_lab
    Epigenetics of leukemia - research in the Cosgrove Lab - February 2012
    Cell identity in multi-cellular organisms is determined in part by factors that regulate gene accessibility within the context of eukaryotic chromatin. Post-translational modifications of histone proteins are central in the establishment of heritable gene expression programs through the regulation of chromatin structure. Read more...
  • xiaowen-jon-mac
    A recombination protein identified in mitochondria - Chen Lab - October 2011
    Mitochondrial DNA (mtDNA), encoding integral components of the energy-producing oxidative phosphorylation pathway on the mitochondrial inner membrane, is extremely vulnerable to damages by oxidative, chemical, irradiational and metabolic stresses. Read more...
  • meg
    Biosensor development in the Loh lab - July 2011
    The Loh lab designs protein-based switches as platforms for biosensing. Proteins recognize many interesting ligands, but most proteins don't change their structures upon binding. Read more...
  • student in biochem lab
    Bin3 is required for head development - April 2011
    Several years ago, graduate student Wencheng Zhu discovered a novel methyltransferase calledl Bin3. The function of this protein remained a mystery for a long time. Read more...