Biochemistry and Molecular Biology
Rm. 4265, 766 Irving Ave.
Syracuse, NY 13210
Map & directions
Phone: 315 464-5127
Fax: 315 464-8750
Name: Patricia M Kane, PhD, Chair
The Department of Biochemistry and Molecular Biology offers a highly collaborative research community and an excellent training environment for young scientists.
The field of biochemistry and molecular biology has been transformed in the past decade with the sequencing of the human genome and genomes of other organisms, atomic resolution structures for many important macromolecules, and technological advances that allow integration of this information to address fundamental questions about the structure and function of cells and organisms. These developments create unprecedented opportunities for scientific research and understanding of human health and disease.
- Using disease-associated mutations to understand the biochemical regulation of a multi-subunit histone methyltransferase complex - June 2014
Eukaryotic DNA is compacted into chromatin, which must be continually remodeled to allow for DNA processes such as transcription. The basic repeating unit of chromatin, the nucleosome, is composed of an octomer of histone proteins around which 147 base pairs of DNA is wrapped. One way chromatin remodeling is achieved is by posttransitional modification of histones. Read more...
- Attack of the Killer Severer - in the Amberg Lab- May 2013
Graduate student Dimitra Aggeli, working in the Amberg lab, has discovered how to turn the small actin binding protein into an actin filament destroying machine. Building off the previous work by graduate student Mike Clark, Dimitra has been trying to understand why some of Mike's mutants are hyperactive for actin filament disassembly. Read more...
- Understanding ε-mediated inhibition of bacterial F-type ATP synthase to develop drugs against Mycobacterium tuberculosis in the Duncan Lab- March 2013
Mycobacterium tuberculosis (MTB) is an infectious pathogen that causes Pulmonary Tuberculosis and kills over one million people every year. It is also a major cause of death in HIV patients. Evolution of extreme drug-resistant strains in MTB poses a serious problem towards its treatment. As a result, there is an ongoing need to develop novel drugs that can effectively fight the resistant strains. Read more...
- New Insight into the Reversible Dissociation of the V-ATPase Revealed by the Wilkens Lab - April 2012
The vacuolar ATPase (V-ATPase) is a rotary molecular motor enzyme that functions to acidify the lumen of subcellular organelles in all eukaryotic cells. V-ATPase function is involved in a number of fundamental cellular processes including pH/ion homeostatis, endocytosis, vesicular traffic and antigen processing. Read more...
- Epigenetics of leukemia - research in the Cosgrove Lab - February 2012
Cell identity in multi-cellular organisms is determined in part by factors that regulate gene accessibility within the context of eukaryotic chromatin. Post-translational modifications of histone proteins are central in the establishment of heritable gene expression programs through the regulation of chromatin structure. Read more...
- A recombination protein identified in mitochondria - Chen Lab - October 2011
Mitochondrial DNA (mtDNA), encoding integral components of the energy-producing oxidative phosphorylation pathway on the mitochondrial inner membrane, is extremely vulnerable to damages by oxidative, chemical, irradiational and metabolic stresses. Read more...
- Biosensor development in the Loh lab - July 2011
The Loh lab designs protein-based switches as platforms for biosensing. Proteins recognize many interesting ligands, but most proteins don't change their structures upon binding. Read more...
- Bin3 is required for head development - April 2011
Several years ago, graduate student Wencheng Zhu discovered a novel methyltransferase calledl Bin3. The function of this protein remained a mystery for a long time. Read more...